中国临床医学2012，Vol.19Issue(6)：575-578,4.
移植肾长期存活受者体内人白细胞抗原抗体对移植肾功能的影响
Effect of Antibodies of Human Leukocyte Antigen on Graft Survival in Long-Term Survived Renal Recipients with Functional Grafts
摘要
Abstract
Objective:To investigate the effect of antibodies of human leukocyte antigen(HLA) on graft survival in long-term survived renal recipients with functional grafts. Methods: A total of 92 long-term survived renal recipients with functional grafts who were treated with cyclosporine-based triple maintenance drug therapy have been enrolled. Post-transplant serum samples from them were screened for anti-HLA antibodies. Results: Before transplantation. HLA-Ⅰ antibodies were found in 27 patients and HLA-Ⅱ antibodies were found in 16 patients . However, HLA-Ⅰ antibodies were found in 12 patients and HLA-Ⅱ antibodies were found in 18 patients at present. Moreover, all of these antibodies were different from those found before transplantation. In these renal recipients with functional renal grafts, the estimated glomerular filtration rates (eGFR) were (66. 52 ± 14. 516) mL/(min · 1. 73 m2) and (69. 09 ± 25. 542) mL/(min · 1. 73 nr) in HLA antibody-positive group(n = 23) and HLA antibody-negative group(n = 69) , and the difference between the two groups was not significant(P>0. 05). Among the 92 recipients, 3 patients(3. 26%) had donor specific anti-HLA antibodies (DSA). The frequency of DSA in this study is lower than that of normal kidney recipients. Conclusions: HLA antibodies in long-term renal grafts are all de novo, not pre-transplant sensitized ones. The status of HLA antibodies has little impact on the function of present renal grafts in long-term survived recipients.关键词
肾移植/人白细胞抗原/抗体/移植肾功能Key words
Kidney transplantation/Human leukocyte antigen/Antibody/Renal allograft function分类
医药卫生引用本文复制引用
曾毅刚,刘志宏,范昱,秦燕,丁言德,沈瑾,邱建新..移植肾长期存活受者体内人白细胞抗原抗体对移植肾功能的影响[J].中国临床医学,2012,19(6):575-578,4.基金项目
国家自然科学基金资助项目(编号:30972997) （编号:30972997）
