中国临床医学2012，Vol.19Issue(6)：679-681,3.
丙泊酚中/长链脂肪乳注射液在全凭静脉麻醉中的有效性和安全性分析
Effect and Safety of Propofol-Lipuro in Total Intravenous Anesthesia
李敏 1黄宇光 2王祥瑞 3薛张纲1
作者信息
- 1. 复旦大学附属中山医院麻醉科,上海 200032
- 2. 北京协和医院麻醉科,北京 100730
- 3. 上海交通大学附属仁济医院麻醉科,上海200127
- 折叠
摘要
Abstract
Objective:To investigate the effect and safety of propofol in a medium- and long-chain triglyceride (MCT/LCT) emulsion (Propofol-Lipuro) in the course of total intravenous anesthesia (TIVA). Methods: As a randomized, blind, positively controlled, multi-center and prospectively clinical study, the study involved 2 groups: trial group (propofol medium- and long-chain triglyceride emulsion group, n= 104) and control group (propofol long-chain triglyceride emulsion group, n=103). General anesthesia was performed according to the unified method of total intravenous anesthesia with target-controlled infusion (TCI) of propofol and remifentanil. Before starting the remifentanil, the target plasma concentration (Cp) of propofol was set at 3 μg/mL until the loss of patient's eyelash reflex. Then TCI of both drugs was used throughout induction and maintenance of anesthesia. Clinical effect of anesthesia and adverse events (AE) during the study were evaluated. Results: There were no significant difference between the two groups in time to loss of eyelash reflex and dosage of propofol needed, and the total dosage of propofol and remifentanil during anesthesia as well. AE incidence was 30. 77% in trial group and 48. 54% in control group. The former was significantly lower than the latter (P<0. 05). Of all the AEs, pain at injection site had the highest incidence in both groups, and its occurrence was 25. 00% in trial group and 44. 66% in control group. The former was significantly lower than the latter (P<0. 05). Conclusions: As compared with LCT emulsion Diprivan, MCT-LCT emulsion Propofol-Lipuro is equally safe and efficacious for induction and maintenance using TIVA. In addition, Propofol-Lipuro can reduce the incidence of injection pain.关键词
静脉麻醉/丙泊酚/靶控输注/注射痛Key words
Intravenous anesthesia/Propofol/Target-controlled infusion/ Pain at injection site分类
医药卫生引用本文复制引用
李敏,黄宇光,王祥瑞,薛张纲..丙泊酚中/长链脂肪乳注射液在全凭静脉麻醉中的有效性和安全性分析[J].中国临床医学,2012,19(6):679-681,3.
