中国临床药学杂志2013，Vol.22Issue(1)：1-5,5.
小叶黑柴胡多糖对小鼠腹腔巨噬细胞功能的影响
Effects of polysaccharides from Bupleurum smithii var.parvifolium on the functions of murine peritoneal macrophages
摘要
Abstract
AIM To investigate the effects of polysaccharides from Bupleurum smithii var. parvifolium (BPs) on the immunologic functions of macrophages. METHODS Murine peritoneal macrophages were obtained and treated with different concentrations of BPs (10, 100,200 mg·L-1) to evaluate their phagocytic capacity towards Escherichia coli, chemotaxis and the ability of nitric oxide(NO) secretion. RESULTS BPs, at the dosage used in this study, obviously promoted phagocytosis towards Escherichia coli and chemotaxis (P < 0.001), but had no effect on NO production of macrophages. BPs 100 and 200 mg·L-1 significantly suppressed lipopolysaccharide-induced NO secretion of macrophages ( P < 0.05). CONCLUSION BPs could enhance the immunologic function of macrophage, but inhibit the secretion of lipopolysaccharide-induced inflammatory mediator.关键词
柴胡多糖/巨噬细胞/吞噬/趋化/一氧化氮Key words
Bupleurum polysaccharide/ macrophage/ phagocytosis/ chemotaxis/ nitric oxide引用本文复制引用
武剑,蒋龙,章蕴毅,力弘,陈道峰..小叶黑柴胡多糖对小鼠腹腔巨噬细胞功能的影响[J].中国临床药学杂志,2013,22(1):1-5,5.基金项目
国家自然科学基金(编号30925042,81274165) （编号30925042,81274165）
科技部"重大新药创制"科技专项(编号2009ZX09502-013,2012ZX09301001-003) （编号2009ZX09502-013,2012ZX09301001-003）
上海市科委基础研究重点项目(编号12JC1400800) （编号12JC1400800）
