中国临床药学杂志2013，Vol.22Issue(1)：19-22,4.
水飞蓟滨对大鼠体内伊马替尼药动学特征的影响
Effect of silybin on the pharmacokinetic characteristics of imatinib in rats
崔虓 1乔丽曼 1徐涛 2林高通 2陈建丽 2王增寿1
作者信息
- 1. 温州医学院附属第二医院药剂科,温州325027
- 2. 温州医学院药学院,温州325027
- 折叠
摘要
Abstract
AIM To study the effect of silybin on the pharmacokinetic characteristics of imatinib in rats. METHODS Twenty male SD rats were divided at random into group Ⅰ and group Ⅱ . Group Ⅰ was given a single dose of 5 g· L-1 silybin with intragastric administration. Group II was given the same amount of com oil.Then 2 groups were given a single dose of 5 g·L-1 imatinib with intragastric administration after 1 h. Blood samples were collected from the tail vein before administration and at 0.5,1,2,3,4,6,8,12,24,36 and 48 h points after imatinib administration. The concentration of imatinib in plasma was detected by HPLC method. The pharmacokinetic parameters were analyzed by DAS program. RESULTS After imatinib administration, imatinib was fitted to the two-compartment model in rats. The main pharmacokinetic parameters of group Ⅰ and group Ⅱ were as follows respectively: pmax were (11. 77 ± 1. 98) and (14.68±2.55)mg·L-1, tmax were(3. 00 ± 0. 68) and(3. 30 ± 0. 68)h, AUCo→48 were( 126. 24 ± 27. 76) and (174.89±34.87)mg·h·L-1, AUCo→48 were(128.43 ±27.74) and(178.07 ± 35.46)mg·h·L-1, t1/2a were(2.40± 0.84) and(4.45±2.52)h,and t1/2β were(7.82±0.87) and(8.72± 1.16)h. When silybin and imatinib were co-administered, imatinib pmax increased by 24.76%, AUCo→48 and AUCo→00 increaed by 38.54%and 38.65% respectively, and t1/2 were relatively extended. CONCLUSION Silybin could increase the pmax and AUC of imatinib and extend the t1/2 of imatinib, then could effect the metabolism of imatinib in rats.关键词
伊马替尼/水飞蓟滨/药动学/HPLC法Key words
imatinib/silybin/ pharmacokinetics/ HPLC引用本文复制引用
崔虓,乔丽曼,徐涛,林高通,陈建丽,王增寿..水飞蓟滨对大鼠体内伊马替尼药动学特征的影响[J].中国临床药学杂志,2013,22(1):19-22,4.
