中国临床药学杂志2013，Vol.22Issue(1)：27-30,4.
国产和进口泮托拉唑钠在输液中的配伍稳定性考察
Compatible stability study of domestic and imported pantoprazole sodium for injection with infusion fluids
陈江飞 1苗彩云 2杨洪明3
作者信息
- 1. 浙江省宁波市第一医院药剂科,宁波315010
- 2. 浙江省宁波市妇女儿童医院药剂科,宁波315012
- 3. 温州医学院药学系
- 折叠
摘要
Abstract
AIM To study the compatible stability of domestic and imported pantoprazole sodium for injection with infusion fluids. METHODS The domestic pantoprazole sodium for injection and imported pantoprazole sodium for injection were added to infusion fluids respectively according to corresponding package inserts, and the mixtures were kept at room temperature for 6 h. The contents of pantoprazole sodium were determined at different time points by HPLC. The outward appearance was observed and the pH value was checked. RESULTS The domestic pantoprazole sodium for injection and imported pantoprazole sodium for injection were stable in 0.9% sodium chloride infusion fluids, and the latter was not stable in 5% or 10% glucose infusion fluids after 4 h with content and pH value reduced gradually. CONCLUSION The 0.9% sodium chloride infusion fluids as solvent should be the first choice for pantoprazole sodium in prescription or medical advice. If necessary, 5% or 10% glucose infusion fluids are used for the imported pantoprazole sodium only, and must be used up within 4 h.关键词
泮托拉唑钠/高效液相色谱法/稳定性Key words
pantoprazole sodium/ HPLC/ stability引用本文复制引用
陈江飞,苗彩云,杨洪明..国产和进口泮托拉唑钠在输液中的配伍稳定性考察[J].中国临床药学杂志,2013,22(1):27-30,4.
