中国美容医学2012，Vol.21Issue(14)：48-49,2.
穿心莲内酯对肺癌细胞NF-κB的活性以及MMP-9表达的影响
Andrographolide on lung cancer cell NF-κB activity and MMP-9 expression influence
罗卫民 1罗湘玉 1刘越峰2
作者信息
- 1. 湖北医药学院附属十堰市太和医院
- 2. 湖北医药学院附属十堰市人民医院 湖北十堰442000
- 折叠
摘要
Abstract
Objective Toobservethe effect of Andrographis Paniculta lactone ( Andrographolide, AD ) on H3255 lung cancer cell growth inhibition of matrix metalloproteinase ( matrix metalloprotein, MMP ) -9 expression and activity of rat, and to study its possible molecular mechanism. Method In vitro culture of H3255 cells , gelatin zymography assay for the detection of the enzyme activity of NF- kB; Western blot p65 subunit nuclear translocation and Ik B phosphorylation status. Results AD in a dose - and time-dependent manner to inhibit the proliferation of H3255 cells; the different concentration of AD can reduce MMP-9 levels of mRNA expression and enzyme activity. Conclusions AD could inhibit the proliferation of lung cancer cells, and its mechanism may be related to the inhibition of I-k B aphosphorylation and inhibition of NF-kB activation, inhibition of MMP-9 activity related to final.关键词
穿心莲内酯/肺癌细胞/核因子κBKey words
andrographolide/ lung cancer cell/ nuclear factor - k B分类
医药卫生引用本文复制引用
罗卫民,罗湘玉,刘越峰..穿心莲内酯对肺癌细胞NF-κB的活性以及MMP-9表达的影响[J].中国美容医学,2012,21(14):48-49,2.
