中国免疫学杂志2012，Vol.28Issue(12)：1096-1102,7.DOI:10.3969/j.issn.1000-484X.2012.12.009
HLA-Ⅰ基因单核苷酸多态性与中国南方汉族女性乳腺癌易感性的相关性研究
Association study between single nucleotide polymorphisms of HLA-Ⅰand susceptibility of breast cancer in southern China
摘要
Abstract
Objective: To investigate whether Human Leukocyte Antigen-Ⅰ ( HLA- 1 ) gene 17 single nucleotide polymorphisms (SNPs) are associated with breast cancer in southern China. Methods: 17 SNPs from HLA- 1 were detected via Sequenom MassArray system. The genotype and allele frequencies were analyzed by Chi-square test in both groups. Logistic regression analyzes the associations between the susceptibility of breast cancer and genotypes. Divided analysis was further carried according to the status of ER, PR and HER-2. Results: All of these 17 SNPs have polymorphism among the detected population. The risk of developing breast cancer in the AT carriers of rs9260682 was significantly higher than that carriers of AA (P = 0. 04) . Furthermore, rs9260682 was also associated with HER-2 status (P = 0. 04) . The polymorphism of rs9260734 was not related to susceptibility of breast cancer (P = 0. 25) , but the carriers of AA in rs9260734 were related to PR status(P = 0. 048) . Conclusion:The polymorphism of rs9260682 is associated with the susceptibility to sporadic breast cancer in southern China and also is related to the HER-2 status, while the carriers of AA in rs9260734 is associated with the PR status.关键词
HLA-Ⅰ/单核苷酸多态性/乳腺癌/易感性Key words
HLA- Ⅰ / Single nucleotide polymorphisms/ Breast cancer/ Susceptibility分类
医药卫生引用本文复制引用
佟琳,杨学习,李粉霞,孙敏英,刘民锋,董建宇,郭昭泽,叶长生..HLA-Ⅰ基因单核苷酸多态性与中国南方汉族女性乳腺癌易感性的相关性研究[J].中国免疫学杂志,2012,28(12):1096-1102,7.基金项目
本文受广州市科技攻关计划(2008A1-E4151)和教育部博士点基金(20104433120016)资助 （2008A1-E4151）
