中国免疫学杂志2012，Vol.28Issue(12)：1129-1133,1135,6.DOI:10.3969/j.issn.1000-484X.2012.12.016
初诊成人自身免疫性糖尿病心血管疾病风险评估
Evaluation of the cardiovascular disease risk in newly diagnosed adult with latent autoimmune diabetes
摘要
Abstract
Objective: To investigate the cardiovascular disease risk of the newly diagnosed adult latent autoimmune diabetes ( LADA) . Methods: After determination of diabetes autoantibodies ,132 cases newly diagnosed diabetes were divided into LADA group (n = 60) and type 2 diabetes mellitus (T2DM) group (n =72) . At the same time,46 cases from physical examination center were selected in normal controls group (NC group) , whoes age and body mass index matched with LADA group. The high-sensitivity C-reac-tive protein ( hs-CRP) level and the carotid intima medial thickness ( CIMT) in three groups were compared. Results: 1. The concentration of hs-CRP and the levels of CIMT in the LADA group was significantly higher than NC group, (P<0. 01, P<0.05) , and in LADA without atherosclerosis ( AS) group also higher than NC group ( P < 0. 05 ) . The risk stratification of cardiovascular disease u-sing the levels of hs-CRP, the percentage of moderate risk group and high risk group in the LADA group was markedly elevated than NC group(P< 0.001, P<0.001). 2. Through compared the levels of hs-CRP and CIMT, there were no significant difference between LADA group and T2DM group(P >0. 05) , also were between LADA without AS group and T2DM without AS group(P >0. 05) . There were no statistical significance between LADA group and T2DM group in the incidence of AS and carotid atherosclerosis plaque(P = 0. 489, P = 0. 920) , the proportion of moderate risk group and high risk group of cardiovascular disease between two group were also no significant difference ( P > 0.05, P>0.05). 3. In LAD A group, LDL-C, FPG, HbAlc, 2hPG, hs-CRP showed a significant linear correlation with CIMT(P = 0. 001-0. 044) . Conclusion: The elevated hs-CRP levels and CIMT levels in newly diagnosed LADA indicated that its risk of cardiovascular disease was increased. The hs-CRP and CIMT levels in newly diagnosed LADA and newly diagnosed T2DM was no significant difference .关键词
成人隐匿性自身免疫糖尿病/高敏C-反应蛋白/颈动脉内膜中层厚度/心血管疾病Key words
Latent autoimmune diabetes in adults/ High-sensitivity C-reactive protein/ Carotid intima-media thickness/ Cardiovascular disease分类
医药卫生引用本文复制引用
杜玉茗,陈艳华,宋利华..初诊成人自身免疫性糖尿病心血管疾病风险评估[J].中国免疫学杂志,2012,28(12):1129-1133,1135,6.基金项目
山东省龙口市人民医院内分泌科,龙口265701 （）
