中国免疫学杂志2012，Vol.28Issue(12)：1136-1138,3.DOI:10.3969/j.issn.1000-484X.2012.12.018
吗替麦考酚酯对老年系统性红斑狼疮患者免疫细胞水平变化的影响
The effect of Mycophenolate Mofeti on the changes of immune cells in old patients with systemic lupus erythematosus
摘要
Abstract
Objective:To investigate the effects of Mycophenolate Mofetil(MMF) on peripheral blood cells including T and B, natural killer(NK) cells in elderly patients with systemic lupus erythematosus(SLE) . Methods: 30 cases of elderly SLE patients were selected as experimental group, at the same time 30 cases of healthy elders were randomly chosen as control group. The changes of T and B peripheral blood cells and NK cells were measured by flow cytometry. 30 cases of patients were randomly divided into 2 groups; intravenous drip(IVD)with prednisone and oral MMF with prednisone. Results:Compared with control, the percentage of CD3+ CD4 + Th cells was significant lower(P <0. 000 1) , while the percentage of CD3 + CD8 + Ts cells was higher(P = 0. 000 3) in the old SLE patients group. The CD3 - (CD16CD56) + NK and CD3 + (CD16CD56) + NKT cells were lower(P <0. 000 1), while the CD3 - CD19+B cells were higher (P =0. 000 2) in the old SLE patients group than those of the healthy control group. A significant positive correlation was obtained between the proportion of CD3~CD19 + B in old SLE patients and SLEDAI(P =0. 003 4,R = 0. 267 8). There were no relation between the percentages of CD3 + CD4 + Th(P =0.071 0,R =0.315 0) , CD3 + CD8+Ts(P = 0. 126, R =0.245 6), NK(P = 0. 098 7 , R = 0. 574 1) cells and SLEDAI. After treatment, the CD3 - CD19 + B were dramatically lower in the GC group than before treatment. After treatment, CD3 + CD4 + Th cells were higer(P = 0. 002) and CD3-CD19+B cells were lower (P< 0.000 l)than before treatment in the MMF combined with GC group. The influence on lymphocyte subsets in the MMF combined with GC group was better than that of the GC group. Conclusion: The changes of immune cell sub populations play an important role in elderly-onset SLE. In combination with glucocorticoid and MMr is better than using hormone alone.关键词
系统性红斑狼疮/老年/淋巴细胞亚群/吗替麦考酚酯Key words
Systemic lupus erythematosus/ Elders/ Lymphocyte subsets/ Mycophenolate Mofetil分类
医药卫生引用本文复制引用
李倩倩,姜振宇,赵令,马宁,王凯,张彦东..吗替麦考酚酯对老年系统性红斑狼疮患者免疫细胞水平变化的影响[J].中国免疫学杂志,2012,28(12):1136-1138,3.基金项目
本文为吉林省科技厅基金项目(201115051) （201115051）
