中国脑血管病杂志2013，Vol.10Issue(1)：18-21,4.DOI:10.3969/j.issn.1672-5921.2013.01.005
基质金属蛋白酶类在颅内动脉瘤中的表达
Expression of the matrix metalloproteinase-2 and 9 in intracranial aneurysms
赵曙虹 1李利敏 1马文群 1张风华 1田伟1
作者信息
- 1. 056001,邯郸,河北省邯郸市中心医院神经外科
- 折叠
摘要
Abstract
Objective To detect the expression of matrix metalloproteinase-2 and 9 ( MMP-2 and MMP-9) in intracranial aneurysms . Methods 17 patients were diagnosed as intracranial aneurysms with DSA and clipped by microsurgery were enrolled in the study (aneurysm group) . Each patients had one aneurysms, 10 were small aneurysms, and 7 were large aneurysms; 11 patients with Hunt-Hess grade Ⅰ to Ⅱ and 6 with Hunt-Hess grade Ⅲ. 15 patients with cerebral trauma but without vascular diseases confirmed by CT and MRI as the control group. HE staining and immunohistochemical staining were used to detect the expression of MMP-2 and MMP-9 in the aneurysm wall and normal vessel wall tissue. The positive index (PI) was calculated. Results ①The positive expression of MMP-2 and MMP-9 in each layer of aneurysm walls in the control group was low. The intima, media, and adventitia of the aneurysm wall tissue had positive expression of MMP-2 and MMP-9 in the aneurysm group. ②The positive expression rates of MMP-2 and MMP-9 in patients of the aneurysm group were 88. 2% and 82. 4% respectively. They were higher than6.7% and 13.3% of the control group. The difference was statistically significant (P＜0.01). ③The PI values of MMP-2 and MMP-9 of the small aneurysms were 5. 1 ± 2. 2 and 5.1 ±4.2 respectively; the PI values of MMP-2 and MMP-9 of the large aneurysms were 4. 6 ± 2. 4 and 4. 1 ± 2. 3 respectively. The differences were not statistically significant (P ＞0.05). ④The PI values of MMP-2 and MMP-9 in patients with Hunt-Hess Ⅰ or Ⅱ were 4. 5 ±1.6 and 4. 2 ± 3. 7 respectively; the PI values of MMP-2 and MMP-9 in patients with Hunt-Hess ≥ Ⅲ were 5.7 ± 3. 1 and5.7±3.1 respectively. The differences were not statistically significant (P ＞0. 05) . Spearman correlation analysis showed that the PI values of MMP-2 and MMP-9 in the aneurysm group were positively correlated (r = 0. 425;P ＜0. 05) . Conclusion The expression of MMP-2 and MMP-9 is higher in the aneurysm wall tissue, and it may be involved in the formation and rupture of intracranial aneurysms.关键词
颅内动脉瘤/显微外科手术/基质金属蛋白酶类/免疫组织化学Key words
Aneurysm/ Microsurgery/ Matrix metalloproteinases/ Immunohistochemistry引用本文复制引用
赵曙虹,李利敏,马文群,张风华,田伟..基质金属蛋白酶类在颅内动脉瘤中的表达[J].中国脑血管病杂志,2013,10(1):18-21,4.
