中国普通外科杂志2013，Vol.22Issue(1)：71-74,4.DOI:10.7659/j.issn.1005-6947.2013.01.017
益生菌应用于肝移植术后患者的临床意义
Beneficial effects of probiotics regimen in patients after liver transplantation
刘海潮 1张水军 1郭文治1
作者信息
- 1. 郑州大学第一附属医院 肝胆胰外科,河南郑州450052
- 折叠
摘要
Abstract
Objective: To investigate the clinical value of using probiotics in patients after liver transplantation.Methods: Fifty-five patients were randomly allocated either to probiotics treatment group or control group after receiving liver transplantation. All patients received immunosuppressant therapy after operation, while those in probiotics treatment group were additionally given bifidobacterium tetravaccine tablets for one week (siliankang, 1.5 g, 3 times daily). The serum levels of total bilirubin (TBIL), alanine aminotransferase (ALT), albumin (ALB) and prealbumin (PA) of the patients were measured before operation and on postoperative day (POD) 2, 5 and 8, respectively. In addition, the incidences of postoperative infection and gastrointestinal adverse events of the patients were observed and recorded. Results: The serum levels of TBIL and ALT between the two groups showed no difference before operation and on POD 2 (all P>0.05), but TBIL and ALT level in probiotics treatment group began to decrease significantly on POD 8 and POD 5 respectively compared with control group (both P<0.05). The serum levels of ALB and PA of the two groups had no obvious difference before operation and on POD 2, but both levels in probiotics treatment group were significantly higher than those of control group on POD 5 and 8 (all P<0.05).The incidences of infection and gastrointestinal adverse events of probiotics group and control group were 4138% vs. 17.24% (P=0.038) and 69.23% vs. 42.31%) (P=0.041) respectively during the first week after operation. Conclusion: Application of probiotics can improve the nutritional status, promote liver function recovery, decrease the inflammatory response, and reduce the incidence of infection and gastrointestinal adverse reaction in patients after liver transplantation.关键词
肝移植/益生菌/手术后并发症/预防与控制Key words
Liver Transplantation/ Probiotics/ Postoperative Complications/prev & control分类
医药卫生引用本文复制引用
刘海潮,张水军,郭文治..益生菌应用于肝移植术后患者的临床意义[J].中国普通外科杂志,2013,22(1):71-74,4.
