中国全科医学2012，Vol.15Issue(31)：3617-3619,3.DOI:10.3969/j.issn.1007-9572.2012.11.016
肺结核患者血清骨桥蛋白和白介素18的检测及意义
Clinical Significance of Serum Osteopontin and Interleukin-18 in Patients with Pulmonary Tuberculosis
郭淑湘 1马冬梅1
作者信息
- 1. 063000 河北省唐山市第四医院内三科
- 折叠
摘要
Abstract
Objective To investigate the levels of osteopontin (OPN) , interleukin -18 (IL-18), interferon -gamma (IFN -γ) and high sensitivity C reaction protein ( hs - CRP) in the serum samples of patients with pulmonary tuberculosis ( TB) . Methods Totally 42 TB patients and 36 normal controls in our hospital were enrolled in the study. Enzyme - linked im-munosorbent assay ( ELISA) was used to determine the levels of OPN, IL-18 and IFN -γ, and Immunoturbidimetric assay for serum hs - CRP level. Results Serum levels of OPN, IL-18, IFN -γ and hs - CRP in TB patients were significantly higher than those in the controls (P < 0. 05). Serum levels of OPN, IL-18, IFN -γ and hs - CRP in patients with high fever (body temperature >39. 0℃ ) were significantly higher than in those with normal body temperature (P <0. 05) . Serum levels of OPN, IL-18 and IFN - γ in patients positive for sputum smear were significantly higher than those in patients negative ( P < 0. 05 ). Serum levels of OPN and IL -18 in patients with severe miliary TB or cavitary TB were significantly higher than those in infiltra-tive TB and tuberculous pleuritis (P<0. 05) . Conclusion OPN and IL-18 can be sensitive indicators for TB activity and severity.关键词
骨桥蛋白/白细胞介素18/干扰素-γ/超敏C-反应蛋白/肺结核Key words
Osteopontin/ Interleukin - 18/ Interferon -γ/ High sensitivity C reaction protein / Pulmonary tuberculosis分类
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郭淑湘,马冬梅..肺结核患者血清骨桥蛋白和白介素18的检测及意义[J].中国全科医学,2012,15(31):3617-3619,3.
