摘要
Abstract
Objective To compare the efficacy of Transmetil (ademetionine) alone and Transmetil combined with ursodeoxycholic acid ( UDCA) in the treatment of severe intrahepatic cholestasis of pregnancy ( ICP) . Methods A total of 32 patients who were admitted to our hospital for severe ICP between January 2005 and June 2009 were randomly divided into two groups using random number table. Patients in group A ( n = 15) were given intravenous injection of 1 000 mg Transmetil once a day plus oral admission of 300 mg UDCA twice a day. Patients in Group B ( n = 17) were only given intravenous injection of 1 000 mg Transmetil once a day. Conventional treatment and care for ICP were given to both groups. Biochemical index (TBA, TB, DB, ALT, and AST) level, pruritus, pregnancy outcome, and perinatal infant conditions of the two groups were recorded and compared at day 0, day 3 and day 7. T test and chi - square test were used. P <0. 05 was considered statistically significant. Results The differences of pruritus score, levels of TBA, TB, DB, ALT, and AST were significant at day 7 compared to day 0 in both groups (P <0. 05). The pruritus score, levels of TBA, TB, DB, ALT, and AST at day 3 and day 7 showed significant difference in both groups ( P < 0. 05 ) except for the pruritus score change in group B (t= 1. 793 , P = 0. 068 ). No significant difference of pruritus score and biomedical index levels was observed between the two groups at day 3 ( P > 0. 05 ). Pregnant week and newborn body weight were significantly different between the two groups ( P < 0. 05 ) . Conclusion Transmetil combined with UDCA is safer and more effective than Transmetil alone in the treatment of severe ICP.关键词
妊娠期肝内胆汁淤积症/思美泰/熊去氧胆酸/治疗结果Key words
Intrahepatic cholestasis of pregnancy/ S - adenosyl - L - methionine/ Ursodeoxycholic acid/ Treatment outcome分类
医药卫生
