中国全科医学2012，Vol.15Issue(34)：3978-3980,3.DOI:10.3969/j.issn.1007-9572.2012.12.015
肥胖伴非酒精性脂肪肝病患儿血管内皮功能的变化研究
Change of Vascular Endothelial Function in Obese Children with Non-alcoholic Fatty Liver Disease
杨丕坚 1李舒敏 1吕以培 1黄中莹 1黄虹1
作者信息
- 1. 535000 广西壮族自治区钦州市第二人民医院内分泌科
- 折叠
摘要
Abstract
Objective To study the relationship between non - alcoholic fatty liver disease (NAFLD) and the vascular endothelial dysfunction in children with obesity. Methods A total of 90 obese children and 34 non - obese children as control were enrolled. Their clinical indicators, biochemical indicators, and flow - mediated dilatation ( FMD) of brachial artery were examined. The obese children were classified into two subgroups according to the diagnosis criteria: obesity group without liver disorder (n = 39) and NAFLD group (n =51). The clinical indicators, biochemical indicators, and FMD of brachial artery were compared among the three groups. Results The FMD prevalence in NAFLD group was (7. 9 ±2. 1)% , lower than (10. 6 ±1.7)% in obesity group and (12. 1 ± 2. 1) % in control group, with a significant difference among the 3 groups ( F = 8. 32, P <0. 05 ). The levels of endothelin - 1 ( ET - 1) , high sensitivity C - reactive protein (hs - CRP) , HOMA insulin resistance index (HOMA-IR) and soluble intercellular adhesion molecule (sICAM -1) in NAFLD were all higher than those in obesity and control groups, with a significant difference among the 3 groups (P <0. 05) . The liner stepwise regression analysis showed that the FMD was negatively correlated with hs - CRP, HOMA - IR and NAFLD ( r = - 0. 487 , - 0. 424, - 0. 407 , P < 0. 05 ) . Conclusion NAFLD may be not only an early marker but also an early state of vascular endothelial dysfunction in obese children.关键词
非酒精性脂肪肝/内皮功能障碍/肥胖/炎症/儿童Key words
Non - alcoholic fatty liver disease/ Endothelial dysfunction/ Obesity/ Inflammation/ Child分类
医药卫生引用本文复制引用
杨丕坚,李舒敏,吕以培,黄中莹,黄虹..肥胖伴非酒精性脂肪肝病患儿血管内皮功能的变化研究[J].中国全科医学,2012,15(34):3978-3980,3.
