中国全科医学2012，Vol.15Issue(34)：3981-3983,3.DOI:10.3969/j.issn.1007-9572.2012.12.016
抗环瓜氨酸肽抗体检测在类风湿性关节炎诊断中的临床价值研究
Value of Anti-cyclic Citrullinated Peptide Antibody Detection in the Diagnosis of Rheumatoid Arthritis
摘要
Abstract
Objective To explore the value of detection of anti - cyclic citndlinated peptide (anti - CCP) antibodies in the diagnosis and treatment of rheumatoid arthritis ( RA) . Methods The level of anti - CCP and RF of 41 RA patients and 85 non - RA patients were respectively detected using microparticle enzyme immunoassay method ( MEIA) and immune nephelome-try. Results The specificity and sensitivity of anti - CCP in detecting RA were 94. 1% and 65. 9% , respectively, and those of RF were 82. 3% and 85. 4% , respectively. The specificity of anti -CCP was higher than that of RF, and the sensitivity of RF was higher than that of anti - CCP (χ2 = 5. 67、4. 23, P < 0. 05) . Conclusion Anti - CCP has lower sensitivity but higher specificity than RF in detecting RA, therefore, the combination of anti - CCP and RF are suggested to raise the diagnostic accuracy of RA.关键词
抗环瓜氨酸肽抗体/类风湿因子/类风湿性关节炎Key words
Anti - cyclic citrullinated peptide/ Rheumatoid factor/ Rheumatoid arthritis分类
医药卫生引用本文复制引用
阮绍均,林勇平,张秀明..抗环瓜氨酸肽抗体检测在类风湿性关节炎诊断中的临床价值研究[J].中国全科医学,2012,15(34):3981-3983,3.基金项目
广东省医学科研基金(A2010252) （A2010252）
