中国全科医学2012，Vol.15Issue(34)：3986-3988,3.DOI:10.3969/j.issn.1007-9572.2012.12.018
糖皮质激素治疗隐源性机化性肺炎的临床疗效研究
Using Glucocorticosteroid to Treat Patients with Cryptogenic Organizing Pneumonia
摘要
Abstract
Objective To investigate the effectiveness of glucocorticosteroid (GC) in treating patients with cryptogenic organizing pneumonia (COP) . Methods Nine cases (group A) were treated first with Methylprednisolone Sodium Succinate for Injection, 160 mg/d, 80 mg/d and 40 rag/d, each dose for three days, then with Prednisone Acetate Tablets 50 mg/d. Then the dose was gradually reduced to 5 mg/d and maintained. Seven cases ( group B) were treated with prednisone 30 mg/d for 14 days, then the dose was gradually reduced to 5 mg/d. Course of treatment for all cases ranged from 8 to 12 months. The clinical manifestations, lung function and imaging results of COP patients were analyzed. Results The clinical manifestations of the 16 COP patients treated was significantly improved within 48 hours after treatment. The imaging lesions were greatly absorbed within 3-7 days. After treatment with glucocorticosteroid, 7 cases recovered and 2 cases improved in group A, and 4 cases recovered, 2 cases improved, 1 case relapsed in group B. The case that relapsed was treated with higher dose and improved. All patients were followed up for 12 - 24 months, and no patients suffered a relapse during that period. Conclusion The treatment for group A is characterized by high initial dose and rapid reduction, while the treatment for group B is characterized by low initial dose and gradual reduction. Both therapies receive positive response from the patients except for one relapse in group B. Therefore , early, appropriate and adequate use of glucocorticosteroid to treat COP will be effective and Lead to optimistic prognosis.关键词
隐源性机化性肺炎/糖皮质激素/疗效Key words
Cryptogenic organizing pneumonia/ Glucocorticoid/ Curative effect分类
医药卫生引用本文复制引用
佟淑平,杜闻博,王琪,敖登其木格,吕福云,卢苗..糖皮质激素治疗隐源性机化性肺炎的临床疗效研究[J].中国全科医学,2012,15(34):3986-3988,3.基金项目
内蒙古自治区自然科学基金项目(2012MS1170) （2012MS1170）
