中国全科医学2013，Vol.16Issue(1)：43-46,4.DOI:10.3969/j.issn.1007-9572.2013.01.013
主动脉球囊反搏对再灌注不良的急性前壁心肌梗死患者血浆脑钠素和心功能的影响
Effect of Intra-aortic Ballon Pump in Patients with Acute Anterior Myocardial Infarction after Unsuccessful Reperfusion Therapy on Serum Brain Natriuretic Peptide and Cardiac Function
摘要
Abstract
Objective To evaluate the effectiveness and the safety of intra - aortic balloon pump ( IABP ) in patients with acute anterior myocardial infarction after unsuccessful reperfusion therapy and its effect on the concentration of serum brain natriuretic peptide ( BNP ) and the values of left ventricular end - diastolic diameter ( LVEDD ) and left ventricular ejection fraction ( LVEF ) . Methods Forty patients with acute anterior myocardial infarction, who underwent unsuccessful reperfusion therapy and optimal medication, were divided as IABP group ( receiving IABP, n = 20 ) and control group ( not receiving IABP, n = 20 ) . At 1, 7, 90 days after admission the plasma concentration of BNP was measured by chemiluminescence immunoassay, and LVEDD and LVEF were measured by echocardiography. Results On the 1 st day of admission, there were no statistical difference between the two groups in values of BNP, LVEDD and LVEF. On the 7th day and the 90th day of admission, the values of BNP in the IABP group were lower than those in the control group [ ( 692 ± 153 ) pg/ml vs. ( 805 ± 151 ) pg/ml, P <0. 05; ( 587 ± 191 ) pg/ml vs. ( 722 ± 174 ) pg/ml, P <0. 05 ] . On the 7th day of admission, no statistical difference was found between the two groups in values of LVEDD and LVEF ( P > 0. 05 ) . On the 90th day of admission, the value of LVEDD in the IABP group were lower than those in the control group [ ( 55 ± 2 ) mm vs. ( 58 ± 3 ) mm, P < 0. 05 ], but in value of LVEF no statistical difference was found ( P > 0. 05 ) . Conclusion On the basis of optimal medication, IABP can further lower the BNP level in patients with acute anterior myocardial infarction after unsuccessful reperfusion therapy, and improve their cardiac functions.关键词
心肌梗死/主动脉内球囊反搏术/脑钠肽/左室舒张末期直径/左室射血分数Key words
Myocardial infarction/ Intra - aortic balloon pump/ Brain natriuretic peptide/ Left ventricular end -diastolic diameter/ Left ventricular ejection fraction分类
医药卫生引用本文复制引用
冯春光,杨向军,付强,王彦炯,曹秋玫,阮红云..主动脉球囊反搏对再灌注不良的急性前壁心肌梗死患者血浆脑钠素和心功能的影响[J].中国全科医学,2013,16(1):43-46,4.基金项目
国家自然基金项目(K112213810) （K112213810）
"江苏省医学领军人才"项目(LJ201140) （LJ201140）
