Abstract
Objective To investigate the role of serum uric acid ( UA ) levels in predicting the non - alcoholic fatty liver ( NAFLD ) in type 2 diabetes mellitus ( T2DM ) patients. Methods Using the research data ( chicTR - TNC -11001489 ) from Kailuan Group, we retrospctively enrollled 2 937 eligible subjects. Based on the the qualifies of the baseline UA levels, these patients were divided into 4 group: group A ( ≤216 μmol/L, n = 738 ), group B ( 216 - μmol/L, n = 749 ), group C ( 263 - μmol/L, n = 722 ), and group D ( > 316 μmol/L, n = 728 ). The incidence of NAFLD as well as age, waist circumference ( WC ), body mass index ( BMI), triglycerides ( TG ), high density lipoprotein cholesterol ( HDL -C ), low density lipoprotein cholesterol ( LDL - C ), total cholesterol ( TC ), and fasting plasma glucose ( FPG ) were recorded. The potential risk factors of NAFLD were analyzed using conditional Logistic regression analysis. Results The incidence of NAFLD was 28. 9% ( 850/2 937 ), among whom males accounted for 28. 1% ( 691/2 460 ), and with statistically significant difference when compared with females (33.3%, 159/477) ( X2 =5.34, P < 0. 05 ). The incidence of NAFLD was 22. 5% ( 166/738 ) in group A, 28. 8% ( 216/749 ) in group B, 29. 5% ( 213/722 ) in group C, and 35. 0% ( 255/728 ) in group D(X2=28. 15, P<0.01). The horizontal comparisons of gender, age, average WC , BMI and TG, HDL - C , LDL - C ,
TC, and FPG among these four groups showed significant difference ( P < 0. 01 ). Taking A as reference group, univariate Logistic regression analysis showed that, the odds ratio (OR ) of NAFLD was 1. 37 [95%C/(1.11, 1.77), P= 0.005), 1.44 [95%C/(1.14, 1.83), P=0.002), and 1. 86 [ 95% CI ( 1. 48, 2.34), P = 0. 000 ) in groups B, C, and D. After the introduction of gener and age, the OR of NAFLD was 1.45 [ 95% CI ( 1.15, 1.84), P = 0. 002 ), 1.52 [ 95% CI ( 1.20, 1.93), P = 0.00l), and 2.03 [95%C/(1.60, 2.57), P = 0. 000 ) in groups B, C, and D. After the further introduction of TG, TC, HDL-C, LDL-C, FPG, and BMI, the OR for NAFLD in groups B, C, and Dwere l.36 [95%CI(1.06, 1.74), P= 0.016), 1.37 [95%CI ( 1.07, 1.74), P = 0.012), and 1. 68 [ 95%CI ( 1. 31 , 2. 17 ), P=0. 000). Con-clusioil T2DM patients are susceptible to NAFLD, with the blood UA level as its independent risk factor.关键词
糖尿病,2型/非酒精性脂肪肝/尿酸/代谢综合征X/人体质量指数Key words
Diabetes mellitus, type 2 /Non - alcoholic fatty liver/Uric acid/Metabolic syndrome X/Body mass分类
医药卫生
