中国全科医学2013，Vol.16Issue(2)：133-135,139,4.DOI:10.3969/j.issn.1007-9572.2013.01.042
不同时间服用复方利血平氨苯喋啶片对非杓型原发性高血压患者血压节律和24小时动态血压的影响研究
Effects of Compound Hypotensive Tablets Administered at Different Time Points on Pressure Rhythm and 24-hour Ambulatory Blood Pressure in Patients with Non-dipper Essential Hypertension
荆珊 1王鸿懿 1孙宁玲1
作者信息
- 1. 100044北京市,北京大学人民医院心内科
- 折叠
摘要
Abstract
Objective To investigate the effects of Compound Hypotensive tablets on blood pressure rhythm and 24 -hour ambulatory blood pressure in treatment of non - dipper essential hypertension. Methods In this multicenter, open - labeled , single armed, and non - controlled study, a total of 461 eligible patients with non - dipper essential hypertension entered the final analysis. Patients were randomized to taking the Compound Hypotensive tablets in the early morning or in the evening ( 1 tablet per day ) for 6 months. The 24 - hour ambulatory blood pressure before and after treatment were measured. Results Compared with the baseline level, the SBP and DBP blood pressure was dramatically reduced after treatment in both two groups ( P<0. 05). After-treatment, the blood control rate was 91. 8% ( 202/220 ) in the early morning group and 91. 5% (206/225) in the evening group. Compared with pre - treatment, the 24 - hour systolic/diastolic blood pressure, day systolic/ diastolic blood pressure, and night systolic/ diastolic blood pressure significantly decreased ( P <0. 05 ). After treatment, the pressure rhythm was changed from non - dipper to dipper in 190 patients ( 104 patients from the early morning group and 86 patients from the evening group ). Conclusion Compound Hypotensive tablets can effectively lower the clinic blood pressure, ambulatory blood pressure, and night blood pressure in patients with non - dipper essential hypertension, wheter taking in the early morning or evening. In addition, it can adjust the abnormal rhythm of blood pressure.关键词
复方利血平氨苯喋啶片/动态血压/高血压/非杓型Key words
Compound hypotensive tablets/Blood pressure determination/Hypertension/Non - dippers分类
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荆珊,王鸿懿,孙宁玲..不同时间服用复方利血平氨苯喋啶片对非杓型原发性高血压患者血压节律和24小时动态血压的影响研究[J].中国全科医学,2013,16(2):133-135,139,4.
