摘要
Abstract
Objective To explore the prevalence of central line associated bloodstream infections ( CLABSI ) in patients receiving parenteral nutrition ( PN ) and their risk factors. Methods A total of 190 patients who were admitted to the intensive care unit of our center and received PN from August 2011 to March 2012 were enrolled in this study. All the patients were inserted with central venous catheters ( CVC ) for PN support. Clinical data were compared between patients with CLABSI or without CLABSI. Results Of these 190 patients, 23 had CLABSI, with an incidence of CLABSI being 16. 96 cases per 1 000 catheter days. Pathogens isolated included 15 strains of gram - positive bacteria, 9 strains of gram - negative bacteria, and 6 strains of fungi. Univariate analysis results showed that, the time of catheter, time of PN, the highest temperature in the extuba-tion, polytrauma, catheter lumen, and glutamine enriched parenteral nutrition were influencing factors of CLABSI. On multiva-riate Logistic analysis, polytrauma [OR = 5. 327, 95% CI( 1.772, 16.013), P =0.003) and duration of PN [ OR = 3. 185 , 95% CI ( 1.073, 9.453 ), P= 0.037] were the independent risk factors of CLABSI. Glutamine enriched parenteral nutrition [ OR=0. 024, 95% CI ( 0. 082, 0. 716 ), P = 0. 01 ] was a protective factor for CLABSI. Conclusion The incidence of CLABSI is high among patients receiving PN, and be resulted from factors including polytrauma and duration of PN. Glutamine enriched parenteral nutrition may help to reduce the incidence of CLABSI. Enteral nutrition should be employed as soon as possible.关键词
肠外营养/中心静脉/感染/导管插入术Key words
Parenteral nutrition/Central venous/Infection/Catheterization分类
医药卫生
