中国全科医学2013，Vol.16Issue(4)：392-395,4.DOI:10.3969/j.issn.1007-9572.2013.02.012
WNK1基因多态性与血管紧张素转换酶抑制剂降压疗效的相关性研究
Correlation of WNK1 Gene Polymorphism with Antihyperactive Effect of Angiotensin Converting Enzyme Inhibitors
摘要
Abstract
Objective To investigate the correlation between the rs880054 and rs2301880 polymorphisms of the WNK1 gene and the blood pressure response to angiotensin - converting enzyme inhibitors ( ACEI ) in patients with essential hypertension. Methods A total 121 patients with mild to moderate essential hypertension, who are Han nationality from a district of Beijing , were recruited. Oral Benazepril was administered to the patients for 8 weeks. Genotyping was performed to identify the polymorphisms of the WNK1 gene. Results There was significant difference in antihyperactive effect between patients with rs880054 and rs2301880 polymorphisms of the WNK1 gene ( P <0. 05 ). There was a significant difference between patients with rs880054 polymorphisms in reduction of diagnostic blood pressure ( DBP ) ( P < 0. 05 ), but no significant difference in systolic blood pressure ( SBP ) ( P >0. 05 ). There was a significant difference between patients with rs2301880 polymorphisms in reduction of DBP, but no significant difference in SBP ( P >0. 05 ). After the treatment there were significant correlation between these two polymorphisms and the reductions in DBP ( rs880054: R2=0.167, P<0.001; rs2301880: R2=0.080, P=0.003), but no correlation was found in SBP. Conclusion The rs880054 and the rs2301880 polymorphisms of the WNK1 gene may be associated with the antihyperactive effect of ACEI in patients with essential hypertension.关键词
高血压/WNK1基因/多态性,单核苷酸/血管紧张素转换酶抑制剂Key words
Hypertension/ WNK1 gene/ Polymorphism, single nucleotide/ Angiotensin converting enzyme inhibitors分类
医药卫生引用本文复制引用
刘洁琳,刘雅,王佐广,王皓,李梅,王丽娟,温绍君..WNK1基因多态性与血管紧张素转换酶抑制剂降压疗效的相关性研究[J].中国全科医学,2013,16(4):392-395,4.基金项目
北京市自然科学基金资助项目(7102045,7120001) （7102045,7120001）
