摘要
Abstract
Objective To investigate the pathogenic bacteria distribution and antimicrobial resistance of nosocomial infection during postoperative chemotherapy in gastric cancer patients. Methods The clinical data of 509 gastric cancer patients undergone postoperative chemotherapy were retrospectively studied. The infection rate, pathogenic bacteria distribution and antimicrobial resistance were analyzed. IL - 6 and IL - 12 expression was examined. Results Nosocomial infection rate was 21. 2% ( 108/509 ), including 89 cases of pulmonary infection, 15 digestive tract infection, 2 urinary tract infection, and 2 incision infection. A total of 149 strains of bacteria were cultured, including 90 strains of Gram - negative bacteria and 59 strains of Gram - positive bacteria. The top two Gram - negative bacteria in strains number were Pseudomonas aeruginosa ( 49 ) and Klebsiella pneumonia ( 37 ). The top two Gram - positive bacteria in strains number were Staphylococcus aureus ( 35 ) and Staphylococcus Haemolyticus ( 21 ). About 2. 9% of the Staphylococcus aureus and no Staphylococcus Haemolyticus were resistant to vancomy-cin. About 4. 1% of Pseudomonas aeruginosa and 2.1% of Klebsiella pneumonia were resistant to imipenem. The expression of IL -6 and IL -12 was increased in the plasma of the infectious patients. Conclusion Pulmonary infection is the most common nosocomial infection in gastric cancer patients undergoing postoperative chemotherapy. The infection is mainly caused by Staphylococcus aureus, Staphylococcus Haemolyticus, Pseudomonas aeruginosa, and Klebsiella pneumonia. Gram - positive bacteria mainly consist of Staphylococcus aureus and Staphylococcus Haemolyticus, which are highly sensitive to vancomycin. Gram - negative bacteria mainly consist of Pseudomonas aeruginosa and Klebsiella pneumonia, which are highly sensitive to imipenem. The plasma level of inflammatory factors increases in infectious patients. Bacteria culture and drug susceptibility test can be used to provide clinical guidance in treating infectious gastric cancer patients undergoing postoperative chemotherapy.关键词
胃肿瘤/化疗/院内感染/病原菌/耐药性Key words
Stomach neoplasms/ Chemotherapy/ Nosocomial infection/ Pathogenic bacteria/ Drug resistance分类
医药卫生
