中国全科医学2013，Vol.16Issue(5)：479-482,4.DOI:10.3969/j.issn.1007-9572.2013.02.039
亚临床甲状腺功能减退与颈动脉内膜中层厚度关系的Meta分析
Associations between Subclinical Hypothyroidism and Carotid Intima Media Thickness:A Meta Analysis
王海龙 1张娜 1张文良 1时景璞1
作者信息
- 1. 110001,辽宁省沈阳市,中国医科大学附属第一医院临床流行病学与循证医学教研室
- 折叠
摘要
Abstract
Objective To explore the associations between subclinical hypothyroidism ( SCH ) and carotid intima -media thickness ( C - IMT ). Methods The literatures on associations of SCH and C - IMT published between January 2001 and August 2011 were retrieved in large databases. The data were extracted and the weighted mean difference ( WMD ) and 95% CI were calculated. Publication bias was assessed by Begg's test. Stata 11. 0 was used to perform meta analysis on the associations between SCH and C - IMT. Results A total of nine articles were included in the study. Analysis results showed that C -IMT of SCH patients and normal controls was significantly different [ WMD = 0. 05 , 95% CI ( 0. 02, 0. 07 ) ]. Subgroup analysis showed that C - IMT were significantly different between SCH patients and normal controls in mean age < 60 years old group, and between hospital based SCH patients and normal controls ( P < 0. 05 ). The differences were significant in both TSH level < 10 mU/L and TSH level ≥10 mU/L groups, and the combined value of WMD in TSH level ≥10 mU/L group was greater than that in TSH level < 10 mU/L group. Conclusion SCH was associated with C - IMT.关键词
亚临床甲状腺功能减退/颈动脉疾病/颈动脉内膜中层厚度/Meta分析Key words
Subclinical hypothyroidism/ Carotid artery diseases/ Carotid intima media thickness/ Meta analysis分类
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王海龙,张娜,张文良,时景璞..亚临床甲状腺功能减退与颈动脉内膜中层厚度关系的Meta分析[J].中国全科医学,2013,16(5):479-482,4.
