摘要
Abstract
Objective To evaluate the role of urine prostate cancer gene 3 ( PCA3 ) assay in the diagnosis of prostate cancer. Methods By searching literature published in PubMed ( from January 1966 to October 2010 ), Cochrane Library ( Section 3, 2010 ), CNKI ( March 1994 to October 2010 ), we collect the relevant cohort or case control studies on urine PCA3 assay for the diagnosis of prostate cancer. The aggregated sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and area under the received operative curve ( AUC ) were calculated using Meta - disc 1. 4 and STATA 11.0 statistic software. Results A total of 11 studies including 2 694 subjects were included in this Meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and AUC were 61% [ 95% CI ( 58% , 64%)], 72% [ 95% CI (70%, 74%)], 2.23 [95%CI(1.88, 2.66)], 0. 54 [ 95%CI(0. 46, 0.62)], and 0. 73 [95%CI(0.69, 0.77)], respectively. Conclusion Urine PCA3 assay has acceptable sensitivity and specificity and can be a used as a non - invasive tool for the diagnosis of prostate cancer.关键词
前列腺癌基因3/前列腺特异抗原/前列腺肿瘤/诊断/Meta分析Key words
Prostate cancer gene 3 / Prostate - specific antigen/ Prostatic neoplasms/ Diagnosis/ Meta Analysis分类
医药卫生
