摘要
Abstract
Objective To investigate the risk factors of non - alcoholic fatty liver disease ( NAFLD ) in patients with non - obese type 2 diabetes mellitus ( T2DM ). Methods Totally 188 patients with non - obese T2DM who were treated in our hospital from Junuary 2011 to June 2012 were enrolled in this study. These patients were divided into the NAFLD group ( n =96 ) and non -NAFLD group ( n =92 ). The demographic data, physical examination results, and laboratory findings were recorded and compared between these two groups. Including gender, age, disease course, blood pressure, and fasting plasma glucose ( FPG ), glycosylated hemoglobin A ( HbA1c ), C - peptide, fasting insulin ( Fins ), blood fat and 2 h postprandial blood glucose were measured. Body mass index ( BMI ), waist - to hip ratio ( WHR ) and insulin resistance index ( HOMA - IR ) were calculated, and the results were statistics analysised. Results The incidence of NAFLD was 51. 1% ( 96/188 ) in our cohort, among whom there were 50 males and 46 females ( x2 =0.019, P>0. 05). Comparison of the WHR, FPG, total cholesterol ( TG ), and high - density lipoprotein showed significant differences between these two groups ( P < 0. 05 ). Logistic regression analysis showed that WHR [ OR = 1.42, 95% CI ( 1. 13, 1.65 )], TG [ OR = 1.37, 95% CI ( 1.08, 1.74 )], and HOMA - IR [ OR = 1. 01, 95% CI ( 0. 98, 1. 04 ) ] were independently positively associated with the incidence of NAFLD in non - obese T2DM patients ( P < 0. 05 ). Conclusion Non - obese T2DM patients are more susceptible to NAFLD, with increased WHR, TG, and HOMA - IR being the independent risk factors.关键词
肥胖症/糖尿病,2型/非酒精性脂肪肝/危险因素Key words
Obesity/ Diabetes mellitus, type 2/ Non - alcoholic fatty liver/ Risk factors分类
医药卫生
