中国全科医学2013，Vol.16Issue(5)：516-519,4.DOI:10.3969/j.issn.1007-9572.2013.02.050
骨化三醇对维持性血液透析患者微炎症及氧化性应激状态的影响研究
Calcitriol Improving Microinflammation and Oxidative Stress in Patients with Maintenance Hemodialysis
刘春秋 1刘雷 1李良志 1何先红 1汤跃武 1史继红 1王军 1吴泽成1
作者信息
- 1. 404000,重庆市,重庆三峡中心医院肾内科
- 折叠
摘要
Abstract
Objective To explore the association of matrix metalloproteases - 9 ( MMP - 9 ) and C - reactive protein ( CRP ) levels with no - flow after primary pecutaneous coronary intervention ( PCI ) in patients with ST segment elevation acute myocardial infarction. Methods A total of 83 patients with ST segment elevation acute myocardial infarction were enrolled in this study. All patients received PCI within 12 hours after disease onset. They were divided into no - reflow group ( n = 17 ) and normal blood flow group ( n = 66 ) after the intervention. The plasma MMP - 9 were measured using double antibody sandwich enzyme -linked immunosorbent assay, and the CRP and troponin I ( cTnl ) were measured using immuno - scatter turbidmetry. Results The no - reflow group had significantly higher plasma levels of MMP, CRP, and cTnl than the normal blood flow group ( P < 0. 05 ). In the no - flow group, MMP - 9 was positively correlated with and cTnl ( r = 0. 290, P = 0. 008 ) while no correlation was found between MMP - 9 and CRP ( r = 0. 018, P = 0. 872 ) and between CRP and cTnl ( r = 0. 139, P = 0. 209 ). Conclusion Plasma MMP - 9, CRP and cTnl levels before PCI may be predictive for the occurrence of no - reflow. Patients at high risk of no - relow should be carefully identified and selected to lower the incidence of no - reflow and increase the clinical cure rate.关键词
维持性血液透析/微炎症状态/氧化性应激/骨化三醇Key words
ST segment elevation acute myocardial infarction/ Angioplasty, transluminal, percutaneous coronary/ Matrix metalloproteases - 9 / No - reflow phenomenon/ C - reactive protein分类
医药卫生引用本文复制引用
刘春秋,刘雷,李良志,何先红,汤跃武,史继红,王军,吴泽成..骨化三醇对维持性血液透析患者微炎症及氧化性应激状态的影响研究[J].中国全科医学,2013,16(5):516-519,4.
