中国全科医学2013，Vol.16Issue(6)：615-617,3.DOI:10.3969/j.issn.1007-9572.2013.02.084
乳腺浸润性导管癌中拓扑异构酶Ⅱ等相关因素表达与腋窝淋巴结转移的关系研究
Correlation of Expressions of Topoisomerase Ⅱ and Other Related Factors with Axillary Lymph Nodes Metastasis in Infiltrating Ductal Carcinoma
王蒙 1张程达 2李真 3刘秀玮 1刘东升 1孟新 1张卫东1
作者信息
- 1. 450001,河南省郑州市,郑州大学公共卫生学院流行病与卫生统计学教研室
- 2. 中国医学科学院北京协和医学院
- 3. 河南省人民医院
- 折叠
摘要
Abstract
Objective To research the expressions of Topoisomerase Ⅱ , nm23 gene, ER, PR and C - erbB - 2 gene in infiltrating ductal carcinoma and their relationship with axillary lymphatic metastasis. Methods The expressions of Topoi-somera Ⅱ , nm23 gene, ER, PR and C -erbB - 2 gene were tested in 101 patients with infiltrating ductal carcinoma using im-munohistochemical methods, and their relationship with lymph node metastasis were analzyed. Results The incidence of axillary lymph node metastasis increased in patients with C - erbB - 2 ( - ),( +),( + + ), and ( + + + ) was 18. 2% ( 2/11 ), 69.7% (23/33), 70.0% (21/30), and 81. 5% (22/27) (x2=14.718, P =0.002). The metastasis rate was 45. 2% in Topoisomerase Ⅱ ( - ) group, which was significantly lower than that in the Topoisomerase Ⅱ ( + ) group ( 77. 1 % ) ( x2= 9. 990, P =0. 002 ). The metastasis rate was 85. 0% in nm23 ( - ) group, which was significantly higher than that in the nm23 ( + ) group ( 55. 7% ) ( x2 = 9. 404, P = 0. 002 ). Logistic multivariate analysis showed that Topoisomerase Ⅱ ( OR = 8. 870, P=0.001 ) and C-erbB-2 ( OR= 1.848, P=0.04l) were risk factors whereas nm23 ( OR =0. 151, P = 0. 008 ) was the protective factors of axillary lymph node metastasis. Conclusion The positive expression of Topoisomerase Ⅱ and C - erbB - 2 gene is associated with infiltrating ductal carcinoma axillary lymph node metastasis. Meanwhile, patients with low nm23 gene expression may have higher risk of axillary lymph node metastasis.关键词
乳腺浸润性导管癌/淋巴结转移/TopoisomeraseⅡ/nm23基因Key words
Infiltrating ductal carcinomas/ Lymph node metastasis/ Topoisomerase Ⅱ / nm23 gene分类
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王蒙,张程达,李真,刘秀玮,刘东升,孟新,张卫东..乳腺浸润性导管癌中拓扑异构酶Ⅱ等相关因素表达与腋窝淋巴结转移的关系研究[J].中国全科医学,2013,16(6):615-617,3.
