中国全科医学2013，Vol.16Issue(6)：633-636,4.DOI:10.3969/j.issn.1007-9572.2013.02.089
ARK5和基质金属蛋白酶2在小细胞肺癌中的表达及其临床意义
Expression of ARK5 and MMP-2 in Small Cell Lung Cancer and Its Clinical Significance
摘要
Abstract
Objective To investigate the expression of ARK5 and MMP - 2 in small cell lung cancer ( SCLC ) and its clinical significance. Methods Immunohistochemistry method was used to detect the expressions of ARK5 and MMP - 2 in 106 cases of SCLC tissues and 40 cases of normal lung tissues. The expressions of ARK5 and MMP - 2 and its relationship with patients' condition and prognosis were analyzed. Results The positive rate of ARK5 and MMP - 2 was 67. 9% ( 72/106 ) and 65. 1% ( 69/106 ) respectively in SCLC group and 5. 0% ( 2/40 ) and 7. 5% ( 3/40 ) respectively in control group, and the difference was statistically significant (x2 were 46. 004 and 38. 540, P <0. 05 ) . The positive rate of ARK5 and MMP -2 was correlated with tumor size, differentiation degree, invasion depth, lymph node metastasis and tumor stage ( P < 0. 05 ). Spearman correlation analysis showed that there was positive correlation between the expressions of ARK5 and MMP - 2 ( r = 0. 878, P <0. 001 ) . Kaplan - Meier survival analysis showed that the five - year survival rate in patients with positive ARK5 expressions was 12. 9% , significantly lower than that of patients with negative expression ( x2 = 30. 077, P < 0. 001 ), while the five -year survival rate in patients with positive MMP -2 expression was 16. 3% , significantly lower than that of patients with negative expression 62. 3% (x2=24. 405 , P <0. 001 ) . Cox multi - factor analysis showed that ARK5 , differentiation degree, tumor stage were independent prognostic factors for SCLC ( P < 0. 05 ) . Conclusion The expressions of ARK5 and MMP - 2 are closely related to differentiation degree, invasion depth, and lymph node metastasis and tumor stage in SCLC patients. ARK5 and MMP - 2 can greatly influence patients' survival rate, and meanwhile, ARK5 is an independent risk factor for the prognosis of SCLC patients.关键词
肺肿瘤/基质金属蛋白酶2/免疫组织化学/肿瘤转移/预后Key words
Lung neoplasms/ Matrix metalloproteinase 2/ Immunohistochemistry/ Neoplasm metastasis/ Prognosis分类
医药卫生引用本文复制引用
陶蓉,郑世良,邱世超,侯成浩,李梦云,宿超,李慧,王云甲,史立宏,张宝刚..ARK5和基质金属蛋白酶2在小细胞肺癌中的表达及其临床意义[J].中国全科医学,2013,16(6):633-636,4.基金项目
国家自然科学基金(81072068) （81072068）
山东省中青年科学家科研奖励基金(2010BSB14050) （2010BSB14050）
潍坊市科学技术发展计划项目(201201230) （201201230）
