中国全科医学2013，Vol.16Issue(6)：637-638,643,3.DOI:10.3969/j.issn.1007-9572.2013.02.090
巴拿巴对糖尿病模型小鼠血糖的影响
Effect of Banaba Capsules on Diabetes Mellitus of Model Mice
摘要
Abstract
Objective To explore the effect of Banaba capsules on the blood glucose of alloxan induced diabetic mice. Methods A total of 200 ICR mice were involved. 30 mice were selected as NC group and other mice were established as diabetes models by intraperitoneal injection of 200 mg/kg alloxan. After 72 h, 120 mice with blood glucose from 15 to 30 mmol/L were randomly divided into MC group, HD group, MD group and LD group with each group 30 mice. The NC group was given 200 mg/kg sodium chloride injection. The HD group, MD group and LD group were given intragastric administration of 100, 20 and 4 mg ·kg-1 · d-1 Banaba capsules dissolved in 5 ml salad oil respectively. The MC group and NC group were given intragastric administration of the same volume of salad oil. The treatment was given for 42 consecutive days and the effect of Banaba capsule on fasting blood glucose and insulin at different times was observed. Results The fasting blood glucose at different times in each group showed statistically significant differences before and after treatment ( ftime×group =25. 166, P <0. 01, Ftime = 10. 318, P <0. 01; fgroup =11. 250, P <0. 01 ) .14 days after administration, the fasting blood glucose in LD group and HD group were lower than MC group; 28 days after administration, the fasting blood glucose in LD group, MD group and HD group were lower than MC group; 42 days after administration, the fasting blood glucose in MD group and HD group were lower than MC group ( P < 0. 05 ) .42 days after administration, the insulin level between each group showed statistically significant difference ( F = 4. 232, P = 0. 005 ) . The insulin level in HD group was significantly higher than MC group ( P < 0. 05 ) . Conclusion Banaba capsules could remarkably lower the level of fasting blood glucose of DM model mice induced by alloxan with dose and time dependence , and it can also promote insulin secretion.关键词
巴拿巴/糖尿病/四氧嘧啶/小鼠Key words
Banaba/ Diabetes mellitus/ Alloxan/ Mice分类
医药卫生引用本文复制引用
方洁,张爱珍,陈建国..巴拿巴对糖尿病模型小鼠血糖的影响[J].中国全科医学,2013,16(6):637-638,643,3.基金项目
2007年浙江省教育厅科研基金项目(20070121) （20070121）
