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Electroacupuncture reduces injury to the blood-brain barrier following cerebral ischemia/ reperfusion injury

Yongjun Peng Hesheng Wang Jianhua Sun Li Chen Meijuan Xu Jihong Chu

中国神经再生研究(英文版)2012,Vol.7Issue(36):2901-2906,6.
中国神经再生研究(英文版)2012,Vol.7Issue(36):2901-2906,6.DOI:10.3969/j.issn.1673-5374-2012.36.007

Electroacupuncture reduces injury to the blood-brain barrier following cerebral ischemia/ reperfusion injury

Electroacupuncture reduces injury to the blood-brain barrier following cerebral ischemia/ reperfusion injury

Yongjun Peng 1Hesheng Wang 1Jianhua Sun 1Li Chen 1Meijuan Xu 1Jihong Chu1

作者信息

  • 1. Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
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摘要

Abstract

This study used electroacupuncture at Renzhong (DU26) and Baihui (DU20) in a rat model of cerebral ischemia/reperfusion injury. Neurological deficit scores, western blotting, and reverse transcription-PCR results demonstrated that electroacupuncture markedly reduced neurological deficits, decreased corpus striatum aquaporin-4 protein and mRNA expression, and relieved damage to the blood-brain barrier in a rat model of cerebral ischemia/reperfusion injury. These results suggest that electroacupuncture most likely protects the blood-brain barrier by regulating aquaporin-4 expression following cerebral ischemia/reperfusion injury.

关键词

electroacupuncture/cerebral ischemia/reperfusion/blood-brain barrier/aquaporin-4/brain edema/rat/Renzhong (DU26)/Baihui (DU20)/brain injury/regeneration/neural regeneration

Key words

electroacupuncture/cerebral ischemia/reperfusion/blood-brain barrier/aquaporin-4/brain edema/rat/Renzhong (DU26)/Baihui (DU20)/brain injury/regeneration/neural regeneration

引用本文复制引用

Yongjun Peng,Hesheng Wang,Jianhua Sun,Li Chen,Meijuan Xu,Jihong Chu..Electroacupuncture reduces injury to the blood-brain barrier following cerebral ischemia/ reperfusion injury[J].中国神经再生研究(英文版),2012,7(36):2901-2906,6.

基金项目

This project was funded by the National Natural Science Foundation of China (Youth),No.81001556. (Youth)

中国神经再生研究(英文版)

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1673-5374

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