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Buyang Huanwu Decoction fraction protects against cerebral ischemia/reperfusion injury by attenuating the inflammatory response and cellular apoptosis

Yulian Jin Liuyi Dong Changqing Wu Jiang Qin Sheng Li Chunyan Wang Xu Shao Dake Huang

中国神经再生研究（英文版）2013，Vol.8Issue(3)：197-207,11.

中国神经再生研究（英文版）2013，Vol.8Issue(3)：197-207,11.DOI:10.3969/j.issn.1673-5374.2013.03.001

Buyang Huanwu Decoction fraction protects against cerebral ischemia/reperfusion injury by attenuating the inflammatory response and cellular apoptosis

Yulian Jin ¹Liuyi Dong ²Changqing Wu ³Jiang Qin ³Sheng Li ³Chunyan Wang ¹Xu Shao ⁴Dake Huang⁵

作者信息

1. Department of Pharmacology,Key Laboratory of Chinese Medicine Research and Development, State Administration of Traditional Chinese Medicine, Anhui Medical University, Hefei 230032, Anhui Province, China
2. Anhui Provincial Children's Hospital, Hefei 230051,
3. Department of Pharmacology, Key Laboratory of Chinese Medicine Research and Development, State Administration of Traditional Chinese Medicine, Anhui Medical University, Hefei 230032, Anhui Province, China
4. Anhui Institute of Materia Medica, Hefei 230022, Anhui Province, China
5. Hefei Qi-xing Medicine and Technology Co., Ltd., Hefei 230088, Anhui Province, China
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摘要

Abstract

Buyang Huanwu Decoction fraction extracted from Buyang Huanwu Decoction contains saponins of Astragalus, total paeony glycoside and safflower flavones. The aim of this study was to demonstrate the neuroprotective effect and mechanism of Buyang Huanwu Decoction fraction on ischemic injury fraction reduced infarct volume and pathological injury in ischemia/reperfusion rats, markedly inhibited expression of nuclear factor-κB and tumor necrosis factor-α and promoted nestin protein expression in brain tissue. Buyang Huanwu Decoction fraction (200 mg/kg) exhibited significant effects, which were similar to those of 100 mg/kg Ginkgo biloba extract. In vitro experimental results viability, decreased the release of lactate dehydrogenase and malondialdehyde levels, and inhibited the rate of apoptosis in HT22 cells following oxygen-glucose deprivation. Buyang Huanwu Decoction fraction (100 mg/L) exhibited significant effects, which were similar to those of 100 mg/L Ginkgo biloba extract. These findings suggest that Buyang Huanwu Decoction fraction may represent a novel, protective strategy against cerebral ischemia/reperfusion injury in rats and oxygen-glucose deprivation-induced damage in HT22 cells in vitro by attenuating the inflammatory response and cellular apoptosis.

关键词

neural regeneration/ traditional Chinese medicine/ Buyang Huanwu Decoction fraction/ ischemia/reperfusion injury/ brain injury/ hippocampus/ neurons/ apoptosis/ inflammatory reaction/ oxidation/ traditional Chinese herbal medicines/ neuroprotection/ grant

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Yulian Jin,Liuyi Dong,Changqing Wu,Jiang Qin,Sheng Li,Chunyan Wang,Xu Shao,Dake Huang..Buyang Huanwu Decoction fraction protects against cerebral ischemia/reperfusion injury by attenuating the inflammatory response and cellular apoptosis [J].中国神经再生研究（英文版）,2013,8(3):197-207,11.

基金项目

This project was supported by a grant from the Major Programs of Anhui Science and Technology Special Funds,No.08010302099 （）

and the Doctor Funds of Anhui Medical University,No.XJ200813. （）

中国神经再生研究（英文版）

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ISSN：1673-5374

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