首页|期刊导航|中国神经再生研究（英文版）|Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica
Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica
Qiuling Xu Tao Liu Shuping Chen Yonghui Gao Junying Wang Lina Qiao Junling Liu
中国神经再生研究（英文版）2013，Vol.8Issue(3)：218-225,8.
中国神经再生研究（英文版）2013，Vol.8Issue(3)：218-225,8.DOI:10.3969/j.issn.1673-5374.2013.03.003
Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica
Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica
摘要
Abstract
In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanli (ST36) and Yanglingquan (GB34). In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold (paw withdrawal latency) was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanli and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus.关键词
neural regeneration/ acupuncture and moxibustion/ chronic neuropathic pain/ electroacupuncture/ acupuncture analgesia/ cumulative effect/ synaptic plasticity/ hypothalamus/ learning and memory/ neurobiology/ grants-supported paper/ photographs-containingKey words
neural regeneration/ acupuncture and moxibustion/ chronic neuropathic pain/ electroacupuncture/ acupuncture analgesia/ cumulative effect/ synaptic plasticity/ hypothalamus/ learning and memory/ neurobiology/ grants-supported paper/ photographs-containing引用本文复制引用
Qiuling Xu,Tao Liu,Shuping Chen,Yonghui Gao,Junying Wang,Lina Qiao,Junling Liu..Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica[J].中国神经再生研究（英文版）,2013,8(3):218-225,8.基金项目
This work was supported by the National Natural Science Foundation of China,No.30472241,90709031 and 30973796 （）
the National Basic Research Program of China for Traditional Chinese Medicine Theory (“973” Program),No.2007CB512505 （“973” Program）
the Natural Foundation of Hainan Province (No.310054) （No.310054）
and a grant from the Health Department of Hainan Province(QiongWei 2010-45). （QiongWei 2010-45）
