首页|期刊导航|中国神经再生研究（英文版）|Cognitive effects of atypical antipsychotic drugs in first-episode drug-na?ve schizophrenic patients
中国神经再生研究（英文版）2013，Vol.8Issue(3)：277-286,10.DOI:10.3969/j.issn.1673-5374.2013.03.011
Cognitive effects of atypical antipsychotic drugs in first-episode drug-na?ve schizophrenic patients
Cognitive effects of atypical antipsychotic drugs in first-episode drug-na?ve schizophrenic patients
摘要
Abstract
Cognitive impairment is a core feature of schizophrenia. The present randomized open study enrolled antipsychotic-na?ve patients who were experiencing their first episode of schizophrenia. After baseline neurocognitive tests and clinical assessment, subjects were randomly assigned to olanzapine, risperidone and aripiprazole treatment groups. A battery of neurocognitive tests showed that risperidone produced cognitive benefits in all five cognitive domains, including verbal learning and memory, visual learning and memory, working memory, processing speed, and selective attention; olanzapine improved processing speed and selective attention; and aripiprazole improved visual learning and memory, and working memory. However, the three atypical antipsychotic drugs failed to reveal any significant differences in the composite cognitive scores at the study endpoint. In addition, the three drugs all significantly improved clinical measures without significant differences between the drugs after 6 months. These results suggest that the atypical antipsychotics, olanzapine, risperidone and aripiprazole may improve specific cognitive domains with similar global clinical efficacy. In clinical practice, it may be feasible to choose corresponding atypical antipsychotics according to impaired cognitive domains.关键词
neural regeneration/ clinical practice/ olanzapine/ risperidone/ aripiprazole/ schizophrenia/ cognition/ memory/ grant-supported paper/ neuroregenerationKey words
neural regeneration/ clinical practice/ olanzapine/ risperidone/ aripiprazole/ schizophrenia/ cognition/ memory/ grant-supported paper/ neuroregeneration引用本文复制引用
Juan Wang,Maorong Hu,Xiaofeng Guo,Renrong Wu,Lehua Li,Jingping Zhao..Cognitive effects of atypical antipsychotic drugs in first-episode drug-na?ve schizophrenic patients [J].中国神经再生研究（英文版）,2013,8(3):277-286,10.基金项目
The study was sponsored by the National Key Project of Scientific and Technical Supporting Programs Funded by the Ministry of Science & Technology of China,No.2007BAI17B04 （）
the National Natural Science Foundation of China,No.30900485 （）
and the National R&D Special Fund for Health Professions,No.201002003. （）
