首页|期刊导航|中国神经再生研究（英文版）|Neuroprotective role of fibronectin in neuron-glial extrasynaptic transmission
中国神经再生研究（英文版）2013，Vol.8Issue(4)：376-382,7.DOI:10.3969/j.issn.1673-5374.2013.04.010
Neuroprotective role of fibronectin in neuron-glial extrasynaptic transmission
Neuroprotective role of fibronectin in neuron-glial extrasynaptic transmission
摘要
Abstract
Most hypotheses concerning the mechanisms underlying Parkinson's disease are based on altered synaptic transmission of the nigrostriatal system. However, extrasynaptic transmission was recently found to affect dopamine neurotransmitter delivery by anisotropic diffusion in the extracellular matrix, which is modulated by various extracellular matrix components such as fibronectin. The present study reviewed the neuroprotective effect of fibronectin in extrasynaptic transmission. Fibronectin can regulate neuroactive substance diffusion and receptor activation, and exert anti- neuroinflammatory, adhesive and neuroprotective roles. Fibronectin can bind to integrin and growth factor receptors to transactivate intracellular signaling events such as the phosphatidylinositol 3-kinase/protein kinase B pathway to regulate or amplify growth factor-like neuroprotective actions. Fibronectin is assembled into a fibrillar network around cells to facilitate cell migration, molecule and ion diffusion, and even drug delivery and treatment. In addition, the present study analyzed the neuroprotective mechanism of fibronectin in the pathogenesis of Parkinson's disease, involving integrin and growth factor receptor interactions, and discussed the possible therapeutic and diagnostic significance of fibronectin in Parkinson's disease.关键词
neural regeneration/ neurodegenerative diseases/ Parkinson's disease/ fibronectin/ integrin/ extrasynaptic transmission/ neuroglia/ neuroprotection/ grants-supported paper/ photographs-containing paper/ neuroregenerationKey words
neural regeneration/ neurodegenerative diseases/ Parkinson's disease/ fibronectin/ integrin/ extrasynaptic transmission/ neuroglia/ neuroprotection/ grants-supported paper/ photographs-containing paper/ neuroregeneration引用本文复制引用
Jintang Wang,Ling Yin,Zheng Chen..Neuroprotective role of fibronectin in neuron-glial extrasynaptic transmission[J].中国神经再生研究（英文版）,2013,8(4):376-382,7.基金项目
This work was supported by a grant from the National Science and Technology Infrastructure Platform,Ministry of Science and Technology,No.2005DKA32400. （）
