中国神经再生研究（英文版）2013，Vol.8Issue(5)：397-403,7.DOI:10.3969/j.issn.1673-5374.2013.05.002
Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury Electrophysiological changes and long-term efficacy
Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury Electrophysiological changes and long-term efficacy
Liqing Yao 1Chuan He 1Ying Zhao 1Jirong Wang 1Mei Tang 1Jun Li 1Ying Wu 1Lijuan Ao 1Xiang Hu2
作者信息
- 1. Department of Rehabilitation, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China
- 2. Shenzhen Beike Cell Engineering Research Institute, Shenzhen 518057, Guangdong Province, China
- 折叠
摘要
Abstract
Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time < 3 months), but the safety and long-term efficacy of this treatment need further exploration. In this study, 25 patients with traumatic spinal cord injury (injury time > 6 months) were treated with human umbilical cord blood stem cells via intravenous and intrathecal injection. The follow-up period was 12 months after transplantation. Results found that autonomic nerve functions were restored and the latent period of somatosensory evoked potentials was reduced. There were no severe adverse reactions in patients following stem cell transplantation. These experimental findings suggest that the transplantation of human umbilical cord blood stem cells is a safe and effective treatment for patients with traumatic spinal cord injury.关键词
neural regeneration/ spinal cord injury/ human umbilical cord blood stem cells/ transplantation/paraplegia/ American Spinal Cord Injury Association score/ neurological function/ secretion/somatosensory evoked potentials/ spasm/ safety/ photographs-containKey words
neural regeneration/ spinal cord injury/ human umbilical cord blood stem cells/ transplantation/paraplegia/ American Spinal Cord Injury Association score/ neurological function/ secretion/somatosensory evoked potentials/ spasm/ safety/ photographs-contain引用本文复制引用
Liqing Yao,Chuan He,Ying Zhao,Jirong Wang,Mei Tang,Jun Li,Ying Wu,Lijuan Ao,Xiang Hu..Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury Electrophysiological changes and long-term efficacy[J].中国神经再生研究（英文版）,2013,8(5):397-403,7.
