中国实验动物学报2013，Vol.21Issue(1)：47-52,后插7-后插8,8.DOI:10.3969/j.issn.1005-4847.2013.01.009
白鲜皮水提物对大鼠心肌缺血再灌注损伤的保护作用
Protective effects of aqueous extract of Cortex dictamni on myocardial ischemia reperfusion injury in rats
摘要
Abstract
Objective To investigate the protective effects of Cortex Dictamni( CD) aqueous extract on the rat models of myocardial ischemia reperfusion. Methods Wistar rats were randomly divided into sham group, ischemia reperfusion model group, positive drug group ( Di Ao Xin Xue Kang) and CD low, moderate and high dose groups (CD aqueous extract 0. 16 , 0. 32 , and 0. 64 g/kg) ( n = 6) . The myocardial ischemia reperfusion injury model was established through occluding the left anterior descending branch of coronary artery for 60 min and removing the ligation later to reperfuse for 30 min in vivo. Different doses of CD aqueous extract were intragastrically administered once per day for 2 weeks. The ECG changes were recorded and myocardial infarct size, MDA contents CK and SOD activity were measured. The histological changes were analyzed. Results CD significantly reduced the infarct size in a dose-dependent manner, decreased MDA content, and increased SOD activity. Histological analysis also indicated that CD could protect myocardial cells from ischemia reperfusion injury. Conclusion CD aqueous extract exerts protective effect on myocardial ischemia reperfusion injury in rats. The possible mechanism may be via the inhibition of peroxidation by increasing the antioxidant enzyme activities.关键词
白鲜皮/心肌缺血再灌注损伤/心肌梗死面积Key words
Cortex dictamni/ Myocardial ischemia reperfusion injury/ Myocardial infarct size/ Rat.分类
生物科学引用本文复制引用
徐明亮,王丽丽,李琳,李志强,秦蒙,李津明,许扬..白鲜皮水提物对大鼠心肌缺血再灌注损伤的保护作用[J].中国实验动物学报,2013,21(1):47-52,后插7-后插8,8.基金项目
"重大新药创制"科技重大专项"十一五"及"十二五"计划课题(编号:2011ZX09401-014,2012ZX09103201-012) （编号:2011ZX09401-014,2012ZX09103201-012）
