中国比较医学杂志2013，Vol.23Issue(1)：14-17,后插2,5.DOI:10.3969.j.issn.1671.7856.2013.001.004
袖状胃切除术Wistar大鼠模型建立及初步观察
Establishment and preliminary observation on sleeve gastrectomy model in Wistar rats
张建军 1汪文娟 2吴毅平1
作者信息
- 1. 华中科技大学同济医学院附属同济医院整形美容外科,武汉,430030
- 2. 石河子大学医学院第一附属医院烧伤整形科,石河子,832008
- 折叠
摘要
Abstract
Objective To explore the effect on the body weight and the mucosa and muscularis mucosae thickness of the forestomach on sleeve gastrectomy model in Wistar rat,and to provide morphology base for the further study weight loss mechanisms of sleeve gastrectomy. Methods 20 male Wistar rats were randomly divided into two groups ,12 wistar rats underwent sleeve gastrectomy as the operative group. 8 male Wistar rat underwent a laparotomy and stomach manipulation as the sham operative group. Preoperative weight of the rats was measured ,Preoperative,postoperative first day and every week within postoperative 4 weeks,and then every two weeks for weight measurement. Rats were killed 12 weeks after surgery,then made Paraffin sections,observed the morphological changes of forestomach by histological methods. Results All rats remained alive in the sham operative group ,10 rats remained alive in the operative group. In the Sham operative group,weight gain was achieved obviously after operation,whereas in the operative group,weight gain was achieved until the 2th week. In the operative group,weight gain was significantly lower than in the Sham operative group (P < 0. 05 ) . Postoperative forestomach in the operative group rats compensatory dilatated ,under light microscope mucosa and muscularis mucosa thickness thinning,mucosal shallowing. Conclusion Observation on the forestomach morphology on Sleeve gastrectomy model in Wistar rat may contribute to the further elucidation of weight loss and weight rebound mechanism in the rat model.关键词
袖状胃切除术/模型,动物/前胃/形态学Key words
Sleeve gastrectomy/ Model,animal/ Forestomach/ Morphology分类
医药卫生引用本文复制引用
张建军,汪文娟,吴毅平..袖状胃切除术Wistar大鼠模型建立及初步观察[J].中国比较医学杂志,2013,23(1):14-17,后插2,5.
