中国比较医学杂志2013，Vol.23Issue(2)：35-37,42,4.DOI:10.3969.j.issn.1671.7856.2013.002.009
BRL-37344对离体人肺脏肺泡液体清除的作用
Effect of β3-adrenergic agonist BRL-37344 on alveolar fluid clearance in isolated human lung
摘要
Abstract
Objective To study the effect of β3-adrenergic agonist BRL-37344 on alveolar fluid clearance (AFC) in isolated human lung and the mechanisms involved. Methods Isomolar albumin solution in the presence of 10-4 mol/L to 10-8 mol/L BRL-37344 was injected into the alveolar space in isolated human lung, and the AFC was measured. 10-5 mol/L BRL-37344 combined with phentolamine ( α-receptor antagonist), atenolol ( β1-receptor antagonist), ICI-118551 (β2-receptor antagonist), SR59230A ( β3-receptor antagonist), sodium channel blockers or Na+ /K+ -ATPase blockers were perfused into the alveolar space of isolated human lung. Results 10-4 mol/L to 10-7 mol/ L BRL-37344 significantly increased AFC in the isolated human lung, but 10-8 mol/L BRL-37344 did not increase AFC. The AFC-stimulating effect of BRL-37344 was reduced by SR59230A, amiloride and ouabain. Conclusions BRL-37344 , a β3 -adrenergic agonist, can increase AFC in isolated human lung through promoting the transport by Na +/K+ -ATP ase and accelerate the amelioration of pulmonary edema.关键词
离体人肺脏/肾上腺素能受体激动剂/肺水肿/肺泡液体清除率Key words
Isolated human lung/ Adrenergic agonist/ Lung injury/ Alveolar fluid clearance分类
医药卫生引用本文复制引用
李乃静,李岩,谷秀,李伟,何平..BRL-37344对离体人肺脏肺泡液体清除的作用[J].中国比较医学杂志,2013,23(2):35-37,42,4.基金项目
辽宁省科学技术计划项目(编号:201202245). （编号:201202245）
