中国实用儿科杂志2012，Vol.27Issue(12)：922-924,3.
小儿结核性脑膜炎不同检测方法诊断价值研究
Clinical diagnostic value of different methods for tuberculous meningitis in children
刘彦轩 1刘秋君 2贾安奎 1郭盛菊 1石太新 1尚好珍3
作者信息
- 1. 新乡医学院第一附属医院,河南新乡453100
- 2. 新乡医学院三全学院,河南新乡453000
- 3. 河南省结核病医院,河南卫辉453100
- 折叠
摘要
Abstract
Objective To explore diagnostic value of 5 methods and to seek an appropriate method for the diagnosis of tuberculous meningitis (TBM) in children. Methods A total of 60 children were included in the study.They were divided into two groups: children with TBM (30)and control group(30). Cerebrospinal fluid(CSF)samples from patients of each group were detected by 5 methods and then the sensibility and specificity were statistically analyzed. Results FQ-PCR positive rate of acid-fast bacilli smears and TB cultures,TB-Ab test showed statistically difference(P<0.05). ADA in 30 cases of tuberculous meningitis increased in 14 cases of 30 TBM patients, and in 6 cases of the control group; the sensitivity was of no significant difference,but the specificity(90%)was lower than the FQ-PCR(100%) ,the difference being statistically significant. Smear and culture of cerebrospinal fluid detection rate was not statistically different. The difference of FQ-PCR and ADA in tuberculous meningitis group and control group were statistically significant. Conclusion It is suggested FQ-PCR detection of TB-DNA in CSF is simple,rapid and highly sensitive and specific, which will help early diagnose tuberculous meningitis.关键词
实时荧光定量聚合酶链反应/结核性脑膜炎/脑脊液Key words
real-time fluorescence quantitative polymerase chain reaction/ tuberculous meningitis/ cerebrospinal fluid分类
医药卫生引用本文复制引用
刘彦轩,刘秋君,贾安奎,郭盛菊,石太新,尚好珍..小儿结核性脑膜炎不同检测方法诊断价值研究[J].中国实用儿科杂志,2012,27(12):922-924,3.
