中国实用儿科杂志2013，Vol.28Issue(2)：111-113,3.
中国儿童白血病协作组-08方案治疗儿童标危型急性淋巴细胞白血病中期疗效分析
Treatment outcome of childhood standard-risk acute lymphoblastic leukemia with CCLG-08 protocol
摘要
Abstract
Objective To analyse the treatment outcome of pediatric standard-risk acute lymphoblastic leukemia (SR-ALL) with CCLG-08 protocol, and to provide theoretical evidences for further improving the event-free survival (EFS).Methods A prospective study was carried out on the children with newly diagnosed SR-ALL in our department. Kaplan-Meier methods was used to estimate EFS.Data were analyzed by SPSS. Results A total of 62 patients were recruited and treated with the CCLG-08 protocol.The complete remission rate of induction (CR) was 96.8% ,4 patients (6.5%) dropped out of the protocol.The overall EFS was (95.2 ± 2.7)%, (93.5 ± 3.1)% and (93.5 ± 3.0% in 1 year,2 years and 3 years, respectively.Relapse occurred in 2 patients (3.2.%), all of whom were isolated central nervous system (CNS), no testicular leukemia relapse and second tumor occurred.Three patients died and the mortality rate was 4.8%, with 2 deaths due to chemotherapy complications. Conclusion The tolerance of the CCLG-ALL-08 protocol was favorable, and the EFS rate is close to that of the best level in the world.The standardized clinical risk classification and periodical assessment of treatment effect contribute to lowering relapse rate,reduceing complication, and improving the quality of life.关键词
急性淋巴细胞白血病/儿童/无事件生存Key words
acute lymphoblastic leukemia/childhood/event-free survival分类
医药卫生引用本文复制引用
王方,肖胜军,林鸣,金润铭..中国儿童白血病协作组-08方案治疗儿童标危型急性淋巴细胞白血病中期疗效分析[J].中国实用儿科杂志,2013,28(2):111-113,3.基金项目
国家"十一五"科技支撑计划课题项目(编号:2007BAI04B03) （编号:2007BAI04B03）
