中国实用儿科杂志2013，Vol.28Issue(2)：126-128,3.
影响儿童肝母细胞瘤预后的多因素分析
Multivariate prognostic analysis of hepatoblastoma in children
李丹妮 1于新生 2赵爱芝 3孙立荣1
作者信息
- 1. 青岛大学医学院附属医院小儿血液科,山东青岛26600
- 2. 海阳市妇幼保健院儿科,山东海阳265100
- 3. 胶州市营海街道办事处卫生院,山东胶州266318
- 折叠
摘要
Abstract
Objective To explore the prognostic factors of hepatoblastoma (HB) patients in children. Methods Forty-two patients diagnosed with hepatoblastoma between Jan.2002 and Jun.2011 in our department were divided into two groups: 8 in the unoperated group and 34 in the operated group.The results of their laboratory examinations, pathology, staging and prognosis were reviewed and analyzed by SPSS 17.0.Kaplan-Meier method was used to evaluate survival rates and to draw the survival curve; Log-rank test was used for univariate analysis and Cox regression was used for multivariate analysis. Results The 5-year survival rate in the total 42 cases and in the operated group was 64.4% and 81.4%, respectively. The univariate analysis showed that factors including elevated levels of CRP and LDH,AFP> 10 000 μg/L, embryonal histology, PRETEXT IV and presence of metastases could significantly reduce the 5-year survival rate.Cox multivariate analysis showed that the 5-year survival rate of patients in different subgroups of histology, PRETEXT staging and the AFP level were significantly different (P<0.05). Conclusion The histology,PRETEXT staging and the AFP level are independent factors influencing the prognosis of hepatoblastoma (HB)patients.Early diagnosis and active treatment based on the grasping of the clinical and laboratory characters of the disease can improve the prognosis of the patients.关键词
肝母细胞瘤/预后/Cox回归分析Key words
hepatoblastoma/prognosis/cox regression analysis分类
医药卫生引用本文复制引用
李丹妮,于新生,赵爱芝,孙立荣..影响儿童肝母细胞瘤预后的多因素分析[J].中国实用儿科杂志,2013,28(2):126-128,3.
