中国实用妇科与产科杂志Issue(2)：135-139,5.
卵巢上皮性癌脑转移13例临床分析
Brain metastases from epithelial ovarian carcinoma: clinical analysis of 13 cases
摘要
Abstract
Objective To evaluate the incidence, clinicalpathological characteristics, treatment and prognosis of patients with brain metastases from epithelial ovarian carcinoma. Methods The medical records of 13 cases with brain metastases from epithelial ovarian carcinoma treated in Sun Yat-sen University Cancer Center between January 1995 and December 2009 were analyzed retrospectively. Results Thirteen patients accounted for 0.7% of the 1851 women with epithelial ovarian carcinoma in the period. The median age at diagnosis of brain metastases was 48 years. The median interval between primary diagnosis and brain metastases was 16 months (range, 1 ～38 months). 76.9% (10/13) of the cases had advanced stages at primary diagnosis. Serous adenocarcinoma was the prevalent cell type (10/13). Twelve patients had poorly differentiated tumors, and one had moderately differentiated tumor. The most common symptom of brain metastasis was headache. Intracranial metastatic lesions generally involved cerebrum, followed by cerebellum, while leptomen-inges was an uncommon site involved. Eight patients also had extracranial metastases. The median survival from the diagnosis of brain metastases was 7 months ( range, 0. 5 ～ 172 months) . Most patients (10/13) died within one year. Conclusions Brain metastases from epithelial ovarian carcinoma present an uncommon event and suggest a poor prognosis. It usually occurred in poorly differentiated serous adenocarcinoma patients. Individual comprehensive treatments can alleviate the neurologic symptoms and prolong survival time.关键词
卵巢癌/脑转移/综合治疗/预后Key words
ovarian cancer/ brain metastasis/ combined modality therapy/ prognosis分类
医药卫生引用本文复制引用
徐漫漫,李俊东,黄永文,朱安娜,冯艳玲,肖娟..卵巢上皮性癌脑转移13例临床分析[J].中国实用妇科与产科杂志,2013,(2):135-139,5.基金项目
广东省科技计划项目(2009B030801021) （2009B030801021）
