中国兽医科学2013，Vol.43Issue(1)：91-94,4.
抗菌肽RSRP与常用抗菌药的体外联合药敏试验
Testing the antibacterial activity of antibacterial peptides in rabbit sacculus rotundus combined with eleven kinds of antibiotics in vitro
摘要
Abstract
To investigate the antibacterial activity of antibacterial peptides from rabbit sacculus rotundus(RSRP) and its synergic interaction with antibiotics,the antibacterial activity of RSRP against 8 bacteria was detected by agarose diffusion assay,and then fractional inhibitory concentration indexes(FICs) of eleven kinds of antibiotics and RSRP were measured by the checkerboard microdilution method. Results demonstrated that there were different degree antibacterial activity of RSRP against the eight bacteria,the FIC values ranged from less than 0. 3 to more than 5 ;and there were synergic,additive,indifference and antagonistic interaction between RSRP and the antibiotics. Among them,there was evidently synergic interaction between RSRP and ampicillin sodium,ceftiofur sodium.关键词
圆小囊/抗菌肽/联合药敏试验/分级抑制浓度指数Key words
sacculus rotundus/antibacterial peptides/combined susceptibility test/FIC分类
农业科技引用本文复制引用
陈红伟,吴俊伟,刘娟,张志强,崔龙萍,李英伦..抗菌肽RSRP与常用抗菌药的体外联合药敏试验[J].中国兽医科学,2013,43(1):91-94,4.基金项目
中央高校基本科研业务费专项(XDJK2012C099) （XDJK2012C099）
重庆市科委自然科学基金计划资助项目(cstc2012jjA80013) （cstc2012jjA80013）
