中国体外循环杂志2013，Vol.11Issue(1)：4-7,10,5.
不同剂量氨甲环酸对心脏瓣膜术患者血液的保护作用
Comparison of blood-saving effects of different dose of tranexamic acid in cardiac valvular surgery
摘要
Abstract
Objective To compare the blood - saving effect of different dose of tranexamic acid in cardiac valvular surgery. Methods From February 2009 to February 2010, one hundred and fifty patients were randomly divided into 3 groups according to different dose of tranexamic acid in cardiac valvular surgery: low dose group (n =49), the loading dose was 10 mg/kg and maintenance dose was 2 mg/(kg · h); moderate dose group (n =51), the loading dose was 15 mg/kg and maintenance dose was 8 mg/(kg · h); high dose group (n =50), the loading dose was 30 mg/kg and maintenance dose was 16 mg/(kg · h). The bolus of tranexamic acid was infused intravenously within 30 min after induction followed by continuous infusion until the end of operation. The volume of chest tube drainage was recorded at 6 h and 24 h after operation. The total volume was calculated. The requirement for transfusion of alloge-neic red blood cells (RBC), platelet (Plt) and fresh frozen plasma (FFP) were also recorded. Results There were no significant differences in the volume of chest tube drainage at 6 h ((324. 90 ± 196. 05) vs. (303. 73 ± 185. 03) vs. (255. 31 ± 121. 81) ml), 24 h ((611. 67 ± 281. 56) vs. (601. 50 ± 304. 33) vs. (555. 82 ± 239. 16) ml) and the total volume((744. 48 ± 350. 90) vs. (712. 20 ± 359. 15) vs. (658. 67 ± 290. 07) ml) after operation (P > 0. 05). Moreover, the requirements for transfusion of allogene-ic RBC, Pit and FFP were not significantly different (P > 0. 05). No fatalities occurred during the hospital stay in any of the 3 groups. Conclusion There are no significant differences in transfusion and chest tube drainage in the 3 different dose groups. Therefore, low dose of tranexamic acid is recommended for blood - saving in cardiac valvular surgery.关键词
氨甲环酸/心脏瓣膜手术/血液保护/术后出血/输血Key words
Tranexamic acid/ Cardiac valve surgery/ Blood - saving effect/ Postoperative hemorrhage/ Blood transfusion分类
医药卫生引用本文复制引用
杜英杰,王古岩,杨丽静,石佳,吉冰洋,郑哲..不同剂量氨甲环酸对心脏瓣膜术患者血液的保护作用[J].中国体外循环杂志,2013,11(1):4-7,10,5.基金项目
中央级公益性科研院所基本科研业务费资助(2009-F06) （2009-F06）
