中国现代手术学杂志2012，Vol.16Issue(6)：401-405,5.
大鼠肝移植急性排斥反应模型的建立及相关研究
Establishment and Research of the Models of Rat Acute Hepatic Allograft Rejection
刘歆春 1白剑 2王志敢 1李杰群 1齐海智2
作者信息
- 1. 湖南省长沙市中心医院普外科,长沙430100
- 2. 中南大学湘雅二医院器官移植科,长沙410011
- 折叠
摘要
Abstract
Objective To establish the stable model of rat acute rejection of allograft in inbred rats and research the suitable time to study the model. Methods In 40 cases of Lewis to BN in inbred rats, the orthotopic liver transplantation ( OLT) was performed by modified Kamada 's two-cuff technique. The grades of acute rejection in allografts were judged according to the Banff scheme. Results In all the 40 cases of Lewis to BN in inbred rats, the acute rejection reaction was in a period of rising at the first to the third day, and was rising most rapidly at the third to the seventh day and in the platform at the seventh to ninth day after surgery. Conclusions Lewis to BN rat strain combination is a stable acute rejection model. On the third to the ninth day after operation, it is the suitable time to study the a-cute rejection model.关键词
肝移植/模型,动物/大鼠,近交系/移植物排斥Key words
liver transplantation/ models,animal/ rats, inbred strains/ graft rejection分类
医药卫生引用本文复制引用
刘歆春,白剑,王志敢,李杰群,齐海智..大鼠肝移植急性排斥反应模型的建立及相关研究[J].中国现代手术学杂志,2012,16(6):401-405,5.
