中国畜牧兽医2013，Vol.40Issue(1)：149-152,4.
不同佐剂的奶牛乳房炎多联苗对小鼠免疫机能的影响研究
Research of the Effects of Different Adjuvants Multiple Vaccines for Cow Mastitis Immunization on Mice
摘要
Abstract
This study was performed to investigate the effects of two adjuvants (aluminum hydroxide gel and propolis) multiple vaccines for cow mastitis immunization on mice. Rosette-forming cells (E-RFC) and lymphocyte transformation rate (LTR) of mice were chosen for immune response analysis after immuned at 7, 14, 21, 30 and 45 d, respectively. The results showed that the cellular immune level was improved significantly by both aluminum hydroxide gel and propolis, and reached peak at 30 d (P<0. 01). However, at 30 and 45 d, propolis group showed the extremly higher E-RFC and LTR level than aluminum hydroxide gel group (P<0. 01), which meaned that propolis, compared with aluminum hydroxide gel, could induce stronger sensitization degree of the multiple vaccines to T cell in mice. This study could provide scientific data for elucidating the immunization principle of multiple vaccines and screening the suitable adjuvant for vaccine.关键词
奶牛乳房炎/多联苗/佐剂/免疫Key words
cow mastitis/multiple vaccines/adjuvants/immune分类
农业科技引用本文复制引用
李宏胜,罗金印,王旭荣,李新圃,杨峰,郁杰,徐继英,严作廷..不同佐剂的奶牛乳房炎多联苗对小鼠免疫机能的影响研究[J].中国畜牧兽医,2013,40(1):149-152,4.基金项目
"十二五"国家科技支撑计划(2012BAD12B03) （2012BAD12B03）
甘肃省农业生物技术项目(GNSW-2008-03) （GNSW-2008-03）
甘肃省科技支撑项目(0804NKCA077). （0804NKCA077）
