中国药房2012，Vol.23Issue(45)：4235-4237,3.DOI:10.6039/j.issn.1001-0408.2012.45.05
尼索地平对单硝酸异山梨酯在大鼠体内药动学的影响
Effects of Nisoldipine on Pharmacokinetics of Isosorbide-5-mononitrate in Rats
刘茜 1徐翀 1赵辉 1刘艳芳 1郭孟楠 1郭淑一 1刘泽 1王温才1
作者信息
- 1. 沈阳药科大学药物分析教研室,沈阳110016
- 折叠
摘要
Abstract
OBJECTIVE: To investigate the effect of nisoldipine on pharmacokinetics of isosorbide-5-mononitrate in rats. METHODS: Rats were divided into single drug group (isosorbide-5-mononitrate 5.4 mg·kg-1, i.g.) and drug combination group (isosorbide-5-mononitrate 5.4 mg·kg-1+nisoldipine 5.4 mg·kg-1, i.g.) with 6 rats in each group. The blood samples were collected from venous plexus before medication and within 8.0 h after medication. The plasma concentrations of isosorbide-5-mononitrate were determined by HPLC. Pharmacokinetic parameters were calculated with non-compartmental model using DAS software. RESULTS: The main pharmacokinetic parameters of 2 groups were as follows: t1/2 (2.309 + 0.916) vs. (1.324 ± 0.500) h, Cmax: (2.292 ± 0.700) vs. (2.735 ±0.439) mg·L-1, AUC0~8h,: (3.339 ± 0.663) vs.(4.152 ± 0.719) mg·h·L-1, Vd: (0.881 ± 0.378) vs. (0.462 ± 0.202) L. They were in line with two-compartmental model. Compared with single drug group, t1/2 and Vd of drug combination group decreased significantly (P<0.05) , while other parameters had no obvious change. CONCLUSION: Nisoldipine promotes the elimination of isosorbide-5-mononitrate in rats.关键词
单硝酸异山梨酯/尼索地平/大鼠/高效液相色谱法/药动学Key words
Isosorbide-5-mononitrate/ Nisoldipine/ Rats/ HPLC/ Pharmacokinetics分类
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刘茜,徐翀,赵辉,刘艳芳,郭孟楠,郭淑一,刘泽,王温才..尼索地平对单硝酸异山梨酯在大鼠体内药动学的影响[J].中国药房,2012,23(45):4235-4237,3.
