中国药房2012，Vol.23Issue(45)：4285-4286,2.DOI:10.6039/j.issn.1001-0408.2012.45.22
毛细管气相色谱法测定氯高铁血红素原料药中的冰醋酸残留量
Detection of Residual Glacial Acetic Acid in Hematin Chloride Raw Materials by Capillary Gas Chromatography
摘要
Abstract
OBJECTIVE: To establish the method for the determination of residual glacial acetic acid in hematin chloride raw materials. METHODS: Capillary gas chromatography was adopted. The determination was performed on PEG-20M quartz capillary column with column temperature of 160 ℃. Flame ionization detector was used and the temperature of it was 250 ℃ with nitrogen as carrier gas, and hydrogen and air as auxiliary gas using distilled water as solvent for direct-injection detection. The injection volume was 1.0 μL. RESULTS: The linear range of glacial acetic acid was 0.006 38~0.127 51 mg·mL-1 (r=1.000 0); the average recoveries were 98.98% , 97.76% and 98.86% at low, middle and high concentration (n=9) with RSD of 3.19% ,2.06% and 1.98%. The detection limit was 0.000 76 mg·mL-1. CONCLUSION: The method can be used to detect residual glacial acetic acid in hematin chloride raw materials.关键词
氯高铁血红素/原料药/冰醋酸/残留量Key words
Hematin chloride/ Raw materials/ Glacial acetic acid/ Residues分类
医药卫生引用本文复制引用
严欢,唐明清,毛艳,贺金华,康雨彤..毛细管气相色谱法测定氯高铁血红素原料药中的冰醋酸残留量[J].中国药房,2012,23(45):4285-4286,2.基金项目
新疆维吾尔自治区高技术研究发展计划资助项目(201110103) （201110103）
