中国药房2012，Vol.23Issue(46)：4360-4363,4.DOI:10.6039/j.issn.1001-0408.2012.46.15
辛伐他汀在老年高血脂患者中的群体药动学研究
Population Pharmacokinetics Research of Simvastatin in Elderly Patients with Hyperlipidemia
章袁 1朱立勤 1刘晶 1王浩 1孙秀娟2
作者信息
- 1. 天津医科大学第一中心临床学院,天津300192
- 2. 天津市民政局老年病医院,天津300110
- 折叠
摘要
Abstract
OBJECTIVE: To explore the pharmacokinetics (PK) model of oral simvastatin in elderly patients with hyperlipidemia and provide reference for individualized medication scheme in clinical practice. METHODS: 30 elderly patients with hyperlipidemia, who were orally administered with simvastatin, were enrolled in this study. Blood samples were collected before medication, and 20 days and 62 days after medication. The plasma concentration was determined hy HPLC. The laboratory parameters, such as Cr, ALT, AST, and so on, were determined by biochemical method. Nonlinear mixed effect modeling (NONMEM) was employed to establish the PK model of simvastatin. The effects of age, body weight, CLcr, ALT, AST on parameters of PK were estimated. The final PK model was validated by Bootstrap method. RESULTS: A one-compartment model with first-order absorption and elimination was built. The model, which fixed effects were added into, did not improve the basic model(P>0.05). The typical population values of apparent clearance and apparent volume were: 1 020 L·h-1 and 2 350 L respectively. CONCLUSION: The PK model of oral simvastatin in elderly patients with hyperlipidemia has been established in the study, to provide reference for rational use of simvastatin in the clinic.关键词
辛伐他汀/老年患者/高血脂/群体药动学Key words
Simvastatin/ Elderly patients/ Hyperlipidemia/ Population pharmacokinetics分类
医药卫生引用本文复制引用
章袁,朱立勤,刘晶,王浩,孙秀娟..辛伐他汀在老年高血脂患者中的群体药动学研究[J].中国药房,2012,23(46):4360-4363,4.
