中国药房2012，Vol.23Issue(47)：4417-4418,2.DOI:10.6039/j.issn.1001-0408.2012.47.01
黄芪多糖对肺气虚模型小鼠免疫功能的影响
Effects of Astragalus Polysaccharide on Immune Function of Lung-qi Deficiency Model Mice
摘要
Abstract
OBJECTIVE: To investigate the effects of astragalus polysaccharide(APS)on immune function of lung-qi deficiency model mice. METHODS : Lung-qi deficiency model mice was duplicated by smoking , and model mice were divided into 6 group , i.e. blank control group (constant volume normal saline), model group (constant volume normal saline), Yupingfeng (2.5 g·kg-1), APS high-dose, medium-dose and low-dose groups (600,400,200 mg·kg-1). They were given relevant medicine intragastrically once a day for consecutive 7 days. The spleen index, thymus index, the content of IL-lα and IL-2 in serum and β-defensins 2 of lung tissues were observed. RESULTS: Compared with model group, thymus index of APS high-dose, medium-dose and low-dose groups increased significantly (P<0.05); the contents of IL-la in APS high-dose,medium-dose groups and IL-2 in APS high-dose group in serum increased significantly (P< 0.05), while the content of β-defensins 2 of lung tissues decreased significantly (P< 0.05). CONCLUSION: APS can regulate hypoimmunity caused by lung-qi deficiency, especially improve cellular immune function significantly.关键词
黄芪多糖/免疫调控/肺气虚Key words
Astragalus polysaccharide/ Immuno-regulation/ Lung-qi deficiency分类
医药卫生引用本文复制引用
吴贤波,杜全宇,梁亚丽,马萍..黄芪多糖对肺气虚模型小鼠免疫功能的影响[J].中国药房,2012,23(47):4417-4418,2.基金项目
国家自然科学基金资助项目(81173365) （81173365）
